Evaluation of Urinary Dysfunction in Patients with CANVAS

What this Trial Is About

Researchers are studying urinary symptoms in patients diagnosed with Cerebellar Ataxia, Neuropathy, Vestibular Areflexia Syndrome CANVAS. This condition affects the nervous system and is known to cause urinary system problems in about one third of patients. The main goal is to find out how common these urinary symptoms are and to explore possible complications in both the upper and lower urinary systems. They also want to see how urinary problems relate to the severity of neurological symptoms and signs of autonomic nervous system dysfunction. The study involves a detailed neurological exam using the SARA scale, laboratory tests for kidney function, autonomic nervous system tests including Sudoscan and orthostatic hypotension checks, urinary function questionnaires, urodynamic tests, and ultrasound of the urinary system. These assessments will help characterize the types and severity of urinary dysfunctions and their impact on quality of life. The study collects data at the start and follows participants for up to six months to evaluate biological and structural complications. Participants will undergo various exams and complete questionnaires to monitor urinary and neurological health. Researchers will evaluate urinary flow and autonomic nervous system symptoms, analyzing their relationships with neurological severity. The main outcome is to assess the prevalence of urinary dysfunctions confirmed genetically as CANVAS at the time of inclusion. Safety and study progress are monitored throughout, with the study expected to end in March 2027.

Evaluation of Urinary Dysfunction in CANVAS Patients