Actively Recruiting

Age: 18Years +
All Genders
NCT07202637

Evaluation of the Variation of the Sub-pulmonary Velocity-time Integral to Predict Fluid Responsiveness

Led by Hospital Nord · Updated on 2025-10-02

205

Participants Needed

2

Research Sites

129 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Fluid administration is the first-line treatment in hypovolemic states in critically ill patients. Prediction of fluid responsiveness is possible with echocardiography by assessing the variation of the sub-aortic velocity-time integral (AoVTI) during a passive leg raising test (PLR) or Mini-fluid challenge. However, VTI-Ao measurement is not feasible in all patients due to poor echogenicity. Validation of new fluid-responsiveness indices may facilitate the evaluation in this patient population. Among the available indices, variation of the sub-pulmonary VTI is a potential criterion.

CONDITIONS

Official Title

Evaluation of the Variation of the Sub-pulmonary Velocity-time Integral to Predict Fluid Responsiveness

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patient with measurable sub-pulmonary VTI in at least one of the two windows: parasternal short-axis or subcostal.
  • Patient with measurable sub-aortic VTI in apical 4-chamber view before and after PLR maneuver.
  • Patient with suspected hypovolemia or whose hemodynamic status justifies vasopressor infusion.
Not Eligible

You will not qualify if you...

  • Severe left ventricular dysfunction defined by left ventricular ejection fraction (LVEF) < 30%.
  • Severe right ventricular dysfunction defined by TAPSE < 12 mm.
  • Cardiac arrhythmia or atrial fibrillation.
  • Abdominal compartment syndrome.
  • Amputation of one or both lower limbs.
  • Intracranial hypertension.
  • Pregnant women (ruled out by systematic pregnancy test at ICU admission).
  • Minors.

AI-Screening

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Trial Site Locations

Total: 2 locations

1

Service de réanimation polyvalente - Hopital Nord

Marseille 15, France, 13015

Actively Recruiting

2

Hopital Caremeau Nimes

Nîmes, France, 30029

Actively Recruiting

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Research Team

G

Gary DUCLOS, MD, MSc

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

1

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