Actively Recruiting
Evaluation of Ventilation Defects Downstream of Mucus Plugs in Patients With Severe Asthma
Led by University of Kansas Medical Center · Updated on 2026-04-29
5
Participants Needed
1
Research Sites
78 weeks
Total Duration
On this page
Sponsors
U
University of Kansas Medical Center
Lead Sponsor
P
Polarean Imaging, Plc
Collaborating Sponsor
AI-Summary
What this Trial Is About
In this study, xenon MRI will be used to evaluate regional functional consequences of mucus plugs in the lungs of patients with severe asthma. Mucus plugs will be identified using CT imaging, and xenon MRI will be used to evaluate ventilation and gas exchange impairments in regions of the lungs corresponding to the airways downstream of mucus plugs.
CONDITIONS
Official Title
Evaluation of Ventilation Defects Downstream of Mucus Plugs in Patients With Severe Asthma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adequate completion of informed consent process with written documentation
- Patients 18 - 65 years old
- Physician diagnosis of asthma for > 1 year
- Able to perform reproducible spirometry according to ATS criteria based on clinical PFTs
- Blood eosinophil count > 300 cells/µL and FeNO >25ppb
- Smoking history <10 pack years
- No smoking history (including vapes, cigar, or marijuana use) in the last 3 months
- Approved for asthma therapy with either dupilumab, tezepelumab, or benralizumab as part of their standard of care
You will not qualify if you...
- Respiratory tract infection within the 4 weeks prior to Visit 1
- Body mass index (BMI) > 30 at Visit 1
- One-time doses such as intra-articular injections require a 4-week washout prior to Visit 1
- Asthma-related ER visit within the previous 4 weeks of Visit 1
- Significant concomitant medical illness, including (but not limited to) heart disease, cancer, uncontrolled diabetes, other chronic lung diseases (determined by the Investigator)
- Resting O2 saturation <90% with maximum supplemental O2 delivered by nasal canula
- Positive urine pregnancy test at Visit 1 or at any time while on the study
- Participation in an intervention study (including bronchoscopy) or use of investigative drugs within the past 30 days or plans to enroll in such a trial during the study
- Unable or unlikely to complete study assessments in the opinion of the Investigator
- Study intervention poses undue risk to patient in the opinion of the Investigator
- Conditions that will prohibit MRI scanning determined by the MRI safety screening
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Kansas Medical Center
Kansas City, Kansas, United States, 66160
Actively Recruiting
Research Team
C
Cristal Monge
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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