Actively Recruiting
EVOC - EVs in Obesity and Cardiometabolic Disease
Led by Massachusetts General Hospital · Updated on 2025-11-13
100
Participants Needed
1
Research Sites
382 weeks
Total Duration
On this page
Sponsors
M
Massachusetts General Hospital
Lead Sponsor
A
American Heart Association
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to research the impact of molecular signals from the heart, liver and fat tissue on cardiovascular disease risk, and the presentation of Type II Diabetes and diseases that affect the heart, blood vessels and metabolism (Cardiometabolic Disease). Specifically, the focus is on the content and function of Extracellular Vesicles (EVs), small sacs released from a cell's surface that contain important molecular cargo. The main questions it aims to answer are: 1. What molecular cargo do adipose-tissue EVs carry? 2. How do these cargo impact cardiac and hepatic function? 3. Are changes in EV content related to cardiac function and adiposity with weight loss? Tissue samples from fat tissue and blood samples will be collected from patients receiving bariatric weight loss surgery.
CONDITIONS
Official Title
EVOC - EVs in Obesity and Cardiometabolic Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age greater than or equal to 18 years of age
- Obese (BMI >= 30 kg/m2; for obesity/bariatric surgery group)
- For 20 patients, additional criteria will be presence of pre-diabetes or diabetes (HgbA1c > 5.7 or Fasting blood glucose > 100)
You will not qualify if you...
- Pregnancy (as adjudicated by patient history)
- Prior clinical history of myocardial infarction or valvular heart disease
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114-2696
Actively Recruiting
Research Team
S
Saumya Das, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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