Actively Recruiting
Evolution Over 15 Years of the Clinical, Immune, and Aging Changes in People Living with HIV
Led by Centre de Recherches et d'Etude sur la Pathologie Tropicale et le Sida · Updated on 2025-01-10
120
Participants Needed
1
Research Sites
85 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the long-term clinical, immune, and aging changes in people living with HIV who previously participated in the TEMPO-1 study from 2007-2008. The study aims to understand how immune cells and aging processes evolve over 15 years, comparing HIV-infected individuals to non-infected older adults. This research focuses on how chronic immune activation in HIV leads to immune system exhaustion and contributes to age-related health problems and comorbidities. The study involves two groups: 100 HIV-infected patients and a control group of non-HIV participants, all previously studied in TEMPO-1. Researchers will assess immune and viral markers, including blood cell counts and stem cell function, to track immune aging and inflammatory status. They will compare the immune aging index in the HIV group with controls and analyze clinical events and comorbidities over the 15-year follow-up period. Participants will undergo detailed immune and virological evaluations, including measurements of circulating white blood cells and hematopoietic stem cells. The study will monitor immune system changes and the occurrence of age-related health issues. Data will be collected from medical history, laboratory tests, and immune function assessments to understand the progression of immune aging and its impact on health in people living with HIV.
CONDITIONS
Official Title
Evolution of the Clinical, Immuno-virological and Aging Trajectory of Patients Living With HIV
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Previous participation to the TEMPO-1 study
- 18 years of age or older
- HIV-infected individuals and non-HIV infected control group
- Be affiliated or beneficiary of a social security scheme
- Have signed the consent form.
You will not qualify if you...
- Subject under "sauvegarde de justice" (judicial protection due to temporarily and slightly diminished mental or physical faculties), or under legal guardianship
AI-Screening
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Trial Site Locations
Total: 1 location
1
Hôpital Pitié-Salpêtrière
Paris, France, 75013
Actively Recruiting
Research Team
Y
Yasmine DUDOIT
D
Delphine SAUCE
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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