Study of Changes in Glucose Distribution Volume in Adults with Severe Burns Treated in Intensive Care

What this Trial Is About

This research aims to describe how the initial volume of glucose distribution IDVG changes during the first four days of treatment in adults with severe burns. Severe burns cause a state of low blood volume shock due to inflammation and capillary leak, leading to fluid buildup outside blood vessels. The study focuses on understanding these fluid volume changes to help improve fluid management in burn patients. Participants will receive intravenous glucose to measure the IDVG at various times on admission, and at 4, 8, 16, 24, 48, 72, and 96 hours after the burn injury. A small glucose dose is injected through a central venous line, and blood glucose levels are measured before and after the injection. Other measurements, including intra-thoracic blood volume and extra-vascular lung water, will be taken using a specialized device as part of usual care. During the study, patients will be closely monitored with arterial and central venous catheters to collect blood samples at specified times. Researchers will evaluate glucose distribution volume and its relation to fluid balance, lung water, and patient body surface area. They will also study the association between glucose distribution at 24 to 48 hours and patient outcomes. Participation will last through the first four days of intensive care management, with data collected at regular intervals to understand fluid changes and outcomes.

Evolution of the Initial Distribution Volume of Glucose in the Severe Burned Adults