Actively Recruiting
Evolution of Intestinal Microbiota in Patients With Juvenile Spondylarthropathy According to Typology of Treatment
Led by Centre Hospitalier Universitaire de Nīmes · Updated on 2025-11-17
25
Participants Needed
4
Research Sites
405 weeks
Total Duration
On this page
Sponsors
C
Centre Hospitalier Universitaire de Nīmes
Lead Sponsor
U
University Hospital, Montpellier
Collaborating Sponsor
AI-Summary
What this Trial Is About
Idiopathic juvenile arthritis includes 20% of patients with arthritis with enthesitis or juvenile spondyloarthropathy. This is treated with anti-inflammatory drugs and then followed by biotherapy with DMARDs (Drugs Modifying the Activity of Rheumatic Disease) if the former are insufficient. Methotrexate (MTX) may also be used before these biotherapies. Recently, in adults, a particular profile of intestinal microbiota has been shown to alter the availability of MTX making it in efficient. Knowing that pediatric patients with juvenile spondyloarthropathy have an imbalance of their intestinal flora (dysbiosis) the investigators wanted to explore whether DMARDs could have a similar impact on the microbiota of these young patients and alter the response to treatment.
CONDITIONS
Official Title
Evolution of Intestinal Microbiota in Patients With Juvenile Spondylarthropathy According to Typology of Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged over 6 and under 17 years old (included)
- Diagnosed with arthritis with juvenile enthesitis according to ILAR criteria
- Not treated with methotrexate or biotherapy for at least 3 months
- Not treated with cortisone for over 1 month
- Parents have given written informed consent
- Consent form signed by legal guardian
- Covered by Social Security or private health insurance
You will not qualify if you...
- Enrolled in another category 1 study or participated in one within 3 months prior to inclusion
- Within an exclusion period determined by another study
AI-Screening
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Trial Site Locations
Total: 4 locations
1
Nîmes University Hospital
Nîmes, Gard, France, 30029
Actively Recruiting
2
Montpellier University Hospital, Arnaud de Villeneuve Hospital
Montpellier, Hérault, France, 34295
Actively Recruiting
3
APHM, Hopital Nord
Marseille, France
Actively Recruiting
4
Hopital des enfants, CHU de Toulouse
Toulouse, France
Not Yet Recruiting
Research Team
T
Tu-Anh TRAN, Professor
CONTACT
J
Jean-Philippe LAVIGNE, Professor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
6
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