Actively Recruiting
Evolutive and Functional Bases of Menstruation in Women - 2
Led by Institut National de la Santé Et de la Recherche Médicale, France · Updated on 2025-03-19
20
Participants Needed
1
Research Sites
256 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Menstruation corresponds to the shedding of the uterine lining when fecundation has not occurred. This is a recent evolutionary innovation in primates, and the cellular and genetic changes that led to the acquisition of menstruation are not well understood. Additionally, the uterine lining is poorly characterized in humans across the menstrual cycle, which hinders both evolutionary and medically-relevant analyses. In this study, the research team are collecting uterine endometrial tissue samples from female donors undergoing uterine surgery for benign conditions, to profile gene expression and gene regulatory elements in the major cell types that compose the uterine lining during the secretive phase of the menstrual cycle. The investigators will compare this data to similar samples collected from other primates at the same time point in the female hormonal cycle. The objective is to identify genes that have acquired novel regulation and/or expression patterns and which may be involved in menstruation, as well as better characterize the cellular and molecular pathways at work in the uterine lining of women for translational medicine purposes.
CONDITIONS
Official Title
Evolutive and Functional Bases of Menstruation in Women - 2
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be between 18 and 50 years old.
- Be menstruating at the time of participation.
- Provide written consent.
- Have an indication for hysteroscopy surgery for removal of a polyp, fibroid, endometrial tissue, or uterine malformation scheduled between days 21 and 25 of the menstrual cycle.
- Be covered by social security.
You will not qualify if you...
- Use an intrauterine device contraceptive method during the study or within the previous three months.
- Be pregnant at the time of collection.
- Have been pregnant in the three months prior to collection.
- Have had amenorrhea in the three months prior to collection.
- Have received hormonal treatment within the three months prior to collection.
- Have participated in a clinical study within three months prior to collection.
- Have a personal history of breast, ovarian, uterine body, or cervical cancer.
- Have a diagnosis of endometriosis.
- Have a diagnosis of adenomyosis.
- Have a diagnosis of Lynch syndrome.
- Undergo hysteroscopy for a condition other than those listed in the inclusion criteria.
- Have not given written consent.
- Are breastfeeding.
- Have a body mass index (BMI) less than 18.5 or more than 30.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Pitié salpétrière
Paris, France
Actively Recruiting
Research Team
C
Camille Berthelot, PhD
CONTACT
G
Geoffroy Canlorbe, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here