Actively Recruiting
EVOO and Metabolic Liver Health in MASLD
Led by Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis · Updated on 2026-05-06
60
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
MASLD is currently one of the most common chronic non-communicable diseases and the leading cause of liver-related mortality and morbidity, with a rising prevalence worldwide, especially in the presence of obesity, diabetes, and other cardio-metabolic risk factors. Lifestyle modification, particularly through the Mediterranean Diet, is the first-line intervention, and extra virgin olive oil is a key component thanks to its monounsaturated fatty acids and bioactive compounds with anti-inflammatory and antioxidant effects. Several studies indicate that extra virgin olive oil supplementation, especially within a Mediterranean Diet pattern, reduces hepatic steatosis, improves inflammation, oxidative stress, and glucose and lipid profiles, and may promote weight loss and reduction of fat mass, also through potential effects on the gut microbiota. EFSA recognizes protective effects with a daily intake of at least 20 g of extra virgin olive oil, but it is still unclear whether this amount is optimal for individuals with MASLD, particularly those who are overweight or obese
CONDITIONS
Official Title
EVOO and Metabolic Liver Health in MASLD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- BMI between 20 and less than 30
- Age between 18 and 65 years, both sexes
- Diagnosis of hepatic steatosis confirmed by FibroScan (CAP > 288 dB/m) or Fatty Liver Index (FLI)
You will not qualify if you...
- BMI less than 20 or greater than 30
- Any condition causing liver fat other than those in inclusion criteria
- Pregnancy or breastfeeding
- Severe medical conditions that could affect participation
- Following a special diet
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UOS Data Science
Castellana Grotte, Italy, Italy, 70013
Actively Recruiting
Research Team
R
Rossella Tatoli, Dietician
CONTACT
R
Rossella Donghia, Biologist
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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