Actively Recruiting
Ex VIvo DEtermiNed Cancer Therapy
Led by Sheffield Teaching Hospitals NHS Foundation Trust · Updated on 2025-02-24
600
Participants Needed
1
Research Sites
286 weeks
Total Duration
On this page
Sponsors
S
Sheffield Teaching Hospitals NHS Foundation Trust
Lead Sponsor
U
University of Sheffield
Collaborating Sponsor
AI-Summary
What this Trial Is About
EVIDENT's aim is to test if ex vivo drug screening can predict whether patients with solid cancers will respond, or not respond, to standard care treatments. Patients undergoing standard care surgery to excise their tumour, those undergoing a biopsy, or those having a fluid aspirate of a solid tumour with surplus tissue available after diagnostic use will be eligible for this study. The specimen will then be assessed with ex vivo drug screening utilising all standard therapies and therapies that are more novel and in early stages of development. The results of the ex vivo drug screen will be compared to the cancer's actual response to standard care treatments for those that undergo therapy to determine how effective the test is at predicting treatment response.
CONDITIONS
Official Title
Ex VIvo DEtermiNed Cancer Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 16 years of age or older with known or suspected solid cancer
- Scheduled for surgery, biopsy, fluid aspirate, or TURBT to remove tumor tissue
- Willing to donate fresh tumor tissue surplus to diagnostic use
- Willing to donate a 9ml blood sample
- Able to provide written informed consent
- Previously treated patients with recurrence, progression, or neoadjuvant therapy are eligible
- Patients who have undergone chemotherapy, targeted therapy, immunotherapy, hormone therapy, or radiotherapy for a previous tumor
You will not qualify if you...
- Known diagnosis of blood borne virus (Hepatitis B, Hepatitis C, HIV)
- Current positive COVID-19 infection
AI-Screening
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Trial Site Locations
Total: 1 location
1
Sheffield Teaching Hospitals NHS Foundation Trust
Sheffield, South Yorkshire, United Kingdom, S10 2JF
Actively Recruiting
Research Team
G
Greg Wells, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
6
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