Actively Recruiting
Ex Vivo Drug Sensitivity Testing and Multi-Omics Profiling
Led by Florida International University · Updated on 2025-07-11
65
Participants Needed
1
Research Sites
305 weeks
Total Duration
On this page
Sponsors
F
Florida International University
Lead Sponsor
N
Nicklaus Children's Hospital f/k/a Miami Children's Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Functional precision medicine (FPM) is a relatively new approach to cancer therapy based on direct exposure of patient- isolated tumor cells to clinically approved drugs and integrates ex vivo drug sensitivity testing (DST) and genomic profiling to determine the optimal individualized therapy for cancer patients. In this study, we will enroll relapsed or refractory pediatric cancer patients with tissue available for DST and genomic profiling from the South Florida area, which is 69% Hispanic and 18% Black. Tumor cells collected from tissue taken during routine biopsy or surgery will be tested.
CONDITIONS
Official Title
Ex Vivo Drug Sensitivity Testing and Multi-Omics Profiling
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 21 years or younger at enrollment of any gender, race, or ethnicity
- Suspected or confirmed diagnosis of recurrent or refractory cancer
- Scheduled for or recently had biopsy, tumor excision (solid tumors), or bone marrow aspirate (blood cancers)
- Willing to have blood drawn or buccal swab for genetic testing
- Patients or their parents/legal guardians willing to sign informed consent
- Patients aged 7 to 17 years willing to sign assent
You will not qualify if you...
- No accessible malignant tissue available
- Insufficient amount of excised malignant tissue for drug testing or genetic profiling
- Newly diagnosed tumors
- Tumors with greater than 90% cure rate using safe standard therapy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Nicklaus Children's Hospital
Miami, Florida, United States, 33155
Actively Recruiting
Research Team
D
Diana Azzam, PhD
CONTACT
L
Lillian Garvin
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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