Actively Recruiting
Ex Vivo Expansion (ACT-X)
Led by Mayo Clinic · Updated on 2025-12-23
24
Participants Needed
1
Research Sites
145 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to understand how the body's immune cells respond to a new type of vaccine (neoantigen vaccine) designed to help the immune system recognize and fight cancer. To do this, the study team will collect a research specimen from participants to study their immune cells' reactions to the neoantigen vaccine. This research will help researchers learn more about how these vaccines might work to protect or treat against cancer.
CONDITIONS
Official Title
Ex Vivo Expansion (ACT-X)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically confirmed current or previous solid malignancy or healthy individuals
- Willing to provide mandatory research blood draw or apheresis per protocol
- Provide written informed consent
- Hemoglobin level of at least 10.0 g/dl within 28 days prior to registration
- Absolute neutrophil count of at least 1500/mm^3 within 28 days prior to registration
- Platelet count of at least 100,000/mm^3 within 28 days prior to registration
You will not qualify if you...
- Received intravenous antibiotics within 2 weeks prior to apheresis
- Underwent major surgery within 4 weeks prior to registration
- Received a live vaccine within 30 days prior to registration
- Active hematologic malignancies within 3 years prior to registration
- Immunocompromised or HIV positive patients currently receiving antiretroviral therapy
- History of active tuberculosis, HIV, active hepatitis B or C infection
- Active autoimmune disease requiring systemic treatment within 14 days prior to registration
- Co-morbid systemic illnesses or severe diseases that interfere with safety assessment
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Mayo Clinic in Florida
Jacksonville, Florida, United States, 32224
Actively Recruiting
Research Team
C
Clinical Trials Referral Office
CONTACT
C
Cancer Center Clinical Trials
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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