Studying DNA and Protein Changes in Blood and Tumor Samples from Adults with Metastatic Cancer Undergoing Tumor Removal

What this Trial Is About

Researchers are studying patients diagnosed with aggressive or metastatic cancer to better understand changes in DNA and proteins in tumor tissues and biopsies. The purpose is to identify diagnostic markers and potential drug targets by analyzing samples from blood, cheek cells, and tumor tissue collected during standard care surgical removal or biopsy procedures. This observational study aims to explore molecular differences in tumors and improve understanding of cancer progression and treatment possibilities. Participants undergo collection of blood and buccal cheek samples either before or after their standard care biopsy or tumor removal. Tumor tissue samples are collected during the biopsy or surgery, and medical records are reviewed. Archived tissue or blood samples from previous collections may also be obtained for analysis. The study focuses on integrated genomics and patient-derived cancer models to discover targets or pathways involved in tumor progression. During the study, participants provide biological samples and allow medical record review. Researchers analyze DNA alterations and proteomic changes in tumor and biopsy samples over up to five years. The primary outcomes include identifying DNA and protein changes that may relate to tumor behavior. This study involves no treatment intervention and monitors participants through sample collection and data analysis to better understand malignancies.

Examining Blood and Tissue Samples to Identify Diagnostic Markers in Patients With Metastatic Cancer Undergoing Tumor Removal