Actively Recruiting
Examining Blood and Tissue Samples to Identify Diagnostic Markers in Patients With Metastatic Cancer Undergoing Tumor Removal
Led by Mayo Clinic · Updated on 2025-04-02
50
Participants Needed
1
Research Sites
301 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study characterizes deoxyribonucleic acid (DNA) and proteomic (protein) changes in both biopsies and tumors removed during surgery of patients who have been diagnosed with aggressive/metastatic (that has spread to other places in the body) cancer in order to identify possible diagnostic markers and potential drugs for treating aggressive tumor types. Proteomic analyses include looking at the proteome, or all the proteins expressed, or made by DNA at a specific moment in time. Studying samples of blood, buccal (cheek), and tissue in the laboratory from patients undergoing surgical resection or biopsy may help doctors learn more about the changes that occur in the proteome, DNA alterations, and identify molecular biomarkers for which therapeutic drugs may exist. Studying the DNA in tumor tissue and in blood may also help researchers see if the tumor has important differences.
CONDITIONS
Official Title
Examining Blood and Tissue Samples to Identify Diagnostic Markers in Patients With Metastatic Cancer Undergoing Tumor Removal
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients or their legal representatives must understand and provide written informed consent before starting study procedures
- Must be 18 years of age or older
- Must have a confirmed cancer diagnosis
- Must be medically suitable for a standard biopsy or surgery to obtain tissue, or have archival tissue available for analysis
You will not qualify if you...
- Uncontrolled illnesses, including psychiatric conditions, that limit compliance with the study or ability to give consent
- Tumor is inaccessible for biopsy and no tumor tissue is available for research
- Biopsy poses more than minimal risk to the patient, including:
- Significant bleeding disorders that cannot be corrected
- Severely impaired heart or lung function or unstable blood pressure
- No safe path to the tumor lesion
- Inability to cooperate with or be positioned for the biopsy procedure
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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