Effects of Exercise Timing on Blood Pressure in Adults with Elevated or Mild Hypertension Randomized Study of Morning, Afternoon, and Evening Exercise Sessions Using Individual Biological Clocks

What this Trial Is About

Researchers are investigating how the timing of exercise affects blood pressure in adults aged 18 to 39 years with elevated blood pressure or stage 1 hypertension. The study focuses on how exercising at different times of day influences blood pressure patterns over the following 24 hours, considering the bodys natural circadian rhythms. This trial aims to better understand the time-of-day effects on the blood pressure-lowering response to exercise. Participants will complete three supervised, 30-minute treadmill exercise sessions scheduled according to their individual biological clock, measured by dim-light melatonin onset DLMO. Exercise sessions will occur in the biological morning 10 hours after DLMO, afternoon 15 hours after DLMO, and evening 20 hours after DLMO in a randomized order. Before and after each session, a 24-hour blood pressure assessment will be conducted to evaluate changes. During the study, participants undergo an in-lab biological rhythm assessment to determine their circadian phase. Blood pressure is monitored over 24 hours before and after each exercise session to measure the average daytime systolic blood pressure. The trial involves randomized crossover participation with no masking, and participants blood pressure responses at different exercise times will be compared. This study is expected to last until September 2026.

Examining the Circadian Timing Effects of the Hypotensive Response to Exercise