Actively Recruiting
Examining the Effects of Intra-detrusor Botox at Time of HoLEP in Men With Overactive Bladder Symptoms
Led by Northwestern University · Updated on 2026-04-30
66
Participants Needed
1
Research Sites
162 weeks
Total Duration
On this page
Sponsors
N
Northwestern University
Lead Sponsor
U
University of Calgary
Collaborating Sponsor
AI-Summary
What this Trial Is About
The objective of our multi-center randomized single-blind study is to examine the safety and effect of intra-detrusor OnabotulinumtoxinA injections at the time of holium laser enucleation of the prostate (HoLEP) in men with overactive bladder symptoms with and without urge incontinence.
CONDITIONS
Official Title
Examining the Effects of Intra-detrusor Botox at Time of HoLEP in Men With Overactive Bladder Symptoms
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Males 18 to 89 years old undergoing HoLEP
- Presence of overactive bladder symptoms including frequency, nocturia, urgency, and/or urge incontinence
- Willingness to sign the Informed Consent Form
- Ability to read, understand, and complete patient questionnaires
You will not qualify if you...
- Allergy or hypersensitivity to OnabotulinumtoxinA injections
- Undergoing concurrent ureteroscopy with or without laser lithotripsy, percutaneous nephrolithotomy, or non-urologic surgery during HoLEP
- Anticipated need for perineal urethrostomy at the time of HoLEP
- Prior pelvic radiation or history of bladder cancer with or without BCG therapy
- Lack of decisional capacity
- Active urinary tract infection
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Northwestern Medicine
Chicago, Illinois, United States, 60611
Actively Recruiting
Research Team
A
Alyssa McDonald
CONTACT
A
Allaa Fadl-Alla
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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