Actively Recruiting
Examining Mu Opioid Mechanisms of Ketamine's Rapid Effects in OCD (MKET2)
Led by Stanford University · Updated on 2026-04-24
150
Participants Needed
1
Research Sites
244 weeks
Total Duration
On this page
Sponsors
S
Stanford University
Lead Sponsor
N
National Institute of Mental Health (NIMH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to understand how ketamine works in the brain to bring about a reduction in OCD symptoms.
CONDITIONS
Official Title
Examining Mu Opioid Mechanisms of Ketamine's Rapid Effects in OCD (MKET2)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ages 18 to 65
- Meet the criteria for OCD diagnosis
- Failed at least 1 prior trial of standard first-line OCD treatment
- Agree to lifestyle modifications including fasting before the experimental session, no enrollment in other interventional trials during the study, and commitment to medication study procedures
- Able to provide informed consent
- Healthy volunteers aged 18 to 65 able to provide informed consent
You will not qualify if you...
- Prior use or exposure to naltrexone or ketamine
- Any current or past medical or psychiatric condition making participation unsafe as judged by the investigator or study physician
- Pregnant or nursing, or able to become pregnant and not using effective birth control
- Presence of metal in the body contraindicated for MRI scans
- Current or past use of psychotropic medication in healthy volunteers
- Pregnant or nursing females among healthy volunteers
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Department of Psychiatry & Behavioral Sciences
Stanford, California, United States, 94305
Actively Recruiting
Research Team
P
Pavithra Mukunda, MS
CONTACT
C
Carolyn I Rodriguez, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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