Comparing Online FODMAP Diet and Exposure-Based Cognitive Behavioral Therapy for Irritable Bowel Syndrome A Study to Find What Works Best and How

What this Trial Is About

Researchers are studying how two different treatments work for people with irritable bowel syndrome IBS and for whom they are most effective. The study aims to understand both the factors that influence which treatment works best for each person and the ways these treatments affect IBS symptoms. This is a randomized controlled trial comparing an online dietary program and an online behavioral therapy program for IBS. Participants will be randomly assigned to one of two 12-week online programs. One group will follow the FODMAP diet program, which involves three phases restricting foods high in certain fermentable carbohydrates, reintroducing foods to test tolerance, and personalizing the diet to maintain symptom relief. This program includes support from a dietitian. The other group will participate in Exposure-based Cognitive Behavioral Therapy E-CBT, a six-step behavioral program focusing on changing symptom-related behaviors through self-observation and exposure exercises, with support from a psychologist. During the study, participants will complete weekly assessments of their gastrointestinal symptoms, as well as questionnaires on symptom severity, quality of life, anxiety, food avoidance, and other related measures at baseline, after the 12-week intervention, and at 3- and 6-month follow-ups. Additional data, including stool samples and food diaries, will be collected to understand biological and behavioral changes. Researchers will monitor how symptoms improve and explore what factors affect treatment success, with total participation lasting at least six months after the intervention.

Exclude or Expose in Irritable Bowel Syndrome: What Works for Whom and How?