Actively Recruiting
Exenatide Pharmacokinetics and Pharmacodynamics in Gestational Diabetes
Led by Maisa N. Feghali, MD · Updated on 2026-04-20
13
Participants Needed
1
Research Sites
194 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is being done to study how exenatide, an FDA-approved drug that lowers blood sugar in non-pregnant patients with type II diabetes, works in pregnant women. To do this, the investigators will study the drug's pharmacokinetics (what the body does to the drug; specifically, how quickly your body breaks down and excretes exenatide) and pharmacodynamics (what the drug does to the body; specifically, how effectively exenatide helps the participants' pancreas secrete insulin and how well it controls blood sugar after a meal). There are only two main drug therapies (insulin injections and glyburide pills) currently used for gestational diabetes and not all women achieve good enough blood sugar control without side effects. Therefore, the investigators hope to find out if exenatide might also be helpful in gestational diabetes.
CONDITIONS
Official Title
Exenatide Pharmacokinetics and Pharmacodynamics in Gestational Diabetes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pregnant women carrying a single baby
- Gestational diabetes not requiring medical therapy
- Between 18 and 50 years of age
- Able to give written informed consent
You will not qualify if you...
- Women in the first trimester of pregnancy
- Hematocrit less than 30%
- Current or past treatment with any hypoglycemic agent
- Women with gastrointestinal disease or symptoms such as nausea, vomiting, abdominal pain, or reflux requiring medical treatment
- Women with high triglyceride levels or history of gallbladder or pancreatic disease
- Clinical diagnosis or history of any renal insufficiency or decreased creatinine clearance
AI-Screening
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Trial Site Locations
Total: 1 location
1
Magee Womens Hospital of UPMC
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
Research Team
M
Maisa Feghali, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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