Supervised Exercise Program During Intensive Treatment for Adolescents Aged 12-19 With Cancer in Madrid

What this Trial Is About

Researchers are studying the effects of a supervised exercise program during intensive cancer treatment in adolescents aged 12 to 19 years with newly diagnosed or relapsed malignant extracranial tumors. This study aims to understand how exercise during treatment may benefit heart function and other health factors, focusing on adolescents during their transition to survivorship. The trial is a randomized controlled study conducted in multiple hospitals in Madrid, Spain. Participants are randomly assigned to two groups one receives a supervised exercise program combined with lifestyle counseling, and the other receives standard care with health counseling. The exercise includes three supervised aerobic and resistance sessions per week at the hospital gym, patients rooms during immunodepression phases, or online sessions, plus inspiratory muscle training five days per week. Both groups receive psychological and lifestyle counseling twice monthly. The intervention lasts throughout intensive treatment, approximately 5 to 6 months. Participants undergo assessments at diagnosis, end of treatment, and three months after treatment ends. These include heart function measured by echocardiography, blood pressure, blood lipids, body composition by DXA scans, physical fitness tests, muscle strength, functional mobility, quality of life, fatigue, clinical outcomes like survival and treatment tolerance, as well as biological markers related to metabolism, inflammation, gut microbiome, and immune function. Adherence to exercise is also monitored throughout the study period.

Exercise in Adolescents With Cancer