Actively Recruiting
Can Exercise Ameliorate Immunosenescence and Reduce Relapse in Head and Neck Cancer Patients After Chemoradiotherapy
Led by Chang Gung Memorial Hospital · Updated on 2025-02-28
180
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating whether a specific exercise program can reduce cancer recurrence and improve immune function in patients with head and neck cancer after surgery and chemoradiotherapy. The study focuses on the effects of exercise on immune aging (immunosenescence), which is linked to higher risks of cancer and other diseases. This three-year project aims to find a safe and effective exercise routine that supports recovery and long-term health in these patients. Participants will be randomly assigned to either a group doing high-intensity interval training (HIIT) combined with resistance exercises two to three times a week, starting 4-5 weeks after chemoradiotherapy, or to a control group receiving no exercise intervention. The exercise program lasts for 8 weeks with 24-36 sessions. Researchers will monitor physical activity at home and track outcomes over three years. Throughout the study, participants will have blood tests to measure immune aging markers before and after the exercise program and at follow-up points. They will also complete quality of life questionnaires and have their physical fitness assessed by peak oxygen uptake measurements. Researchers will follow participants for cancer recurrence and survival, collecting data across the full three years to evaluate the effects of exercise on health and immune function.
CONDITIONS
Brief Title
Can Exercise Ameliorate Immunosenescence and Thereby Reduce Relapse in Head and Neck Cancer Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 20 years or older
- Diagnosed with squamous cell carcinoma
- Scheduled to receive or currently receiving concurrent chemoradiotherapy (CCRT)
- ECOG performance status less than 2
- Agree to blood draws, exercise training, and complete questionnaires
You will not qualify if you...
- ECOG performance status 2 or higher
- Unable to tolerate basic exercise or concurrent chemoradiotherapy
- Mental illness or medical conditions that may be worsened by exercise or are unmanageable
- Any medical condition that makes exercise unsuitable
- Decline to participate in trial procedures including exercise, blood draws, or questionnaires
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 8 to 12 weeks starting 4 to 5 weeks after CCRT
Participants who have completed concurrent chemoradiotherapy (CCRT) begin high-intensity interval training (HIIT) exercise two to three times a week, totaling 24 to 36 sessions. Some participants also record physical activities at home to set personalized goals.
Two to three visits per week during exercise training
Duration - Up to 6 months after completing exercise training
Participants are followed to track physical activity, immune indicators, and cancer recurrence rates, with questionnaires and assessments conducted at baseline, 1 month, and 6 months after CCRT.
Follow-up visits at 1 month and 6 months post-CCRT
Trial Site Locations
Total: 1 location
1
TuCheng Hospital
New Taipei City, Taiwan, 23652
Actively Recruiting
Research Team
W
Wan-Chin Kuo
K
Kuo
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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