Actively Recruiting

Phase Not Applicable
Age: 18Years - 35Years
All Genders
ID06662955

Terminal Knee Extension Exercise with Audible Cues on Motor Unit Behavior in Athletes With Anterior Cruciate Ligament Reconstruction

Led by Mahidol University · Updated on 2025-12-12

40

Participants Needed

1

Research Sites

10 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are studying the effects of terminal knee extension (TKE) exercise synchronized with audible cues on muscle activity in athletes who have undergone anterior cruciate ligament (ACL) reconstruction. This research focuses on how adding a metronome pace during TKE exercise may improve neuromuscular control and change motor unit behavior in the vastus medialis muscle, which is important for knee stability after surgery. The study is designed to explore the immediate effects of a single TKE exercise session with or without audible cues. Participants will be randomly assigned to one of two groups: performing TKE exercise either without audible cues or with audible cues delivered via a metronome. Both interventions involve behavioral exercise targeting the knee, applied early in the rehabilitation phase to prevent knee laxity and reduce pain compared to other exercise types. The study runs from enrollment through a two-week treatment period to assess changes in muscle motor unit behavior. During the study, participants will undergo assessments of muscle activity, including measurements of average motor unit firing rate and peak motor unit action potential in the vastus medialis muscle. These assessments occur from enrollment to the end of the two-week treatment. Researchers will monitor participants' ability to perform the exercises and their neuromuscular responses, aiming to understand how sensory cues may enhance rehabilitation outcomes in athletes post-ACL reconstruction.

CONDITIONS

Brief Title

Exercise With Audible Cues on Motor Unit Behavior in Athletes With Anterior Cruciate Ligament Reconstruction

Who Can Participate

Age: 18Years - 35Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Male or female participants who received primary ACL reconstruction within 2 weeks, with or without meniscus repair
  • No or mild resting pain with a numeric rating scale of 3 or less
  • Reconstruction using autograft including hamstrings or bone-patella bone grafts
  • Age between 18 and 35 years
  • Body mass index (BMI) between 18.5 and 25 kg/m²
  • Tegner activity scale level 4 or higher
Not Eligible

You will not qualify if you...

  • Non-weight bearing within 2 weeks after surgery as prescribed by surgeon
  • Hearing problems that prevent hearing the metronome or synchronizing exercises
  • Knee extension limitation due to joint stiffness assessed by passive knee range of motion
  • Unable to actively or passively bend the knee to at least 30 degrees on the operated side
  • History of serious injury or surgery of lower back or lower limbs such as fractures
  • Lower back or lower limb pain within 6 months before the study
  • Use of painkiller medication

AI-Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Outpatient Treatment

Duration - 2 weeks

Participants perform terminal knee extension exercises either with or without audible cues to study the effect on neuromuscular control following ACL reconstruction.

Regular visits during the 2-week exercise period

Trial Site Locations

Total: 1 location

1

Faculty of Physical Therapy, Mahidol University

Salaya, Changwat Nakhon Pathom, Thailand, 73170

Actively Recruiting

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Research Team

K

Komsak Sinsurin, PT, Ph.D., DPT

S

Sakda Nitkotom, B.Sc.

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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