Study of How High-Intensity Exercise Affects Brain Activity and Weight Control in Adults Including Those With and Without Bariatric Surgery

What this Trial Is About

Researchers are studying how high-intensity interval training HIIT affects brain function and molecular pathways related to weight control in adults aged 18 to 70 years. This study includes people with a body mass index over 19, including those who have had bariatric surgery and experienced significant weight regain. The goal is to better understand how exercise influences brain activity and appetite, which could help future obesity treatments. Participants will undergo a 12-week HIIT program with four weekly sessions lasting 28 minutes each. Each session includes a 3-minute warm-up, six cycles of 40 seconds of high-intensity exercise followed by 3 minutes of moderate intensity, and a 3-minute cool-down. These sessions will be supervised and partly conducted at a diabetes center and at home. Before and after the training, participants will complete clinical visits involving medical assessments and brain imaging. During six clinical visits, participants will have tests including blood draws, glucose tolerance tests, metabolic rate measurements, exercise capacity tests, psychometric evaluations, and functional brain MRI scans. Researchers will track changes in brain connectivity, appetite, mood, cognitive function, and molecular markers in blood samples before and after the exercise program. The study will monitor participants progress and gather data to understand the effects of HIIT on brain and weight regulation.

Exercise, Brain Activity, and Weight Maintenance