Actively Recruiting
Exercise, Brain Activity, and Weight Maintenance
Led by Joslin Diabetes Center · Updated on 2025-09-04
15
Participants Needed
1
Research Sites
93 weeks
Total Duration
On this page
Sponsors
J
Joslin Diabetes Center
Lead Sponsor
N
Nutrition Obesity Research Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study aims to explore how HIIT influences brain function, neural and molecular pathways related to weight control, setting the stage for future obesity intervention research.
CONDITIONS
Official Title
Exercise, Brain Activity, and Weight Maintenance
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-70 years
- Body mass index (BMI) >19 kg/m2 and body weight < 250kg
- Participants with bariatric surgery must have experienced clinically significant weight regain, defined as over 10% of their maximum weight lost, within 1 to 5 years post-surgery
- Participants must provide their bariatric surgery operative report
- In good general health without conditions influencing trial outcomes, judged suitable by investigators
- Willing to follow the study protocol for its duration
You will not qualify if you...
- Type 1 diabetes mellitus
- Peripheral neuropathy with insensate feet
- Blood donation within the last 2 months
- Use of beta-blockers
- Current pregnancy or breastfeeding
- Active heart or lung disease
- Severe hypertension (systolic >160 mmHg or diastolic >90 mmHg)
- Inability to exercise for any reason
- Contraindications to exercise testing per ACSM guidelines
- MRI contraindications such as pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments, or foreign objects
- Structural brain lesions like tumors or cortical infarcts
- Other neurologic disorders impacting study, e.g., multiple sclerosis
- History of cardiovascular disease, stroke, or congestive heart failure
- Active hematological, renal, pulmonary, or hepatic disorders
- Active cancer treatment
- History of active alcohol or substance abuse
- Significant systemic illness or unstable medical condition affecting study compliance
- Claustrophobia or inability to tolerate MRI
- Body weight >250 kg or body diameter >70 cm
- Unwilling or unable to attend study visits, neuropsychological testing, or MRI imaging
- Left-handedness
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Joslin Diabetes Center
Boston, Massachusetts, United States, 02215
Actively Recruiting
Research Team
M
Maria Vamvini, MD
CONTACT
L
Laura Simpson, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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