Actively Recruiting

Phase Not Applicable
Age: 40Years - 80Years
All Genders
NCT04426786

Exercise & Brain Energetics in PD

Led by Pacific Parkinson's Research Centre · Updated on 2024-11-06

40

Participants Needed

1

Research Sites

257 weeks

Total Duration

On this page

Sponsors

P

Pacific Parkinson's Research Centre

Lead Sponsor

N

Natural Sciences and Engineering Research Council, Canada

Collaborating Sponsor

AI-Summary

What this Trial Is About

There is increasing evidence that the usage and delivery of energy to the brain, known as brain energetics, is altered in people with Parkinson's disease (PD). This project will explore whether exercise has a positive impact on brain energetics using functional Magnetic Resonance Imaging (fMRI) and Positron Emission Tomography (PET) brain scanning in PD subjects. PD subjects will be scanned before and after a supervised exercise program to investigate the effect of exercise on brain energetics. In a separate study, the investigators will also scan healthy volunteers to compare brain energetics in the healthy brain with the brain energetics data in PD subjects acquired in this study.

CONDITIONS

Official Title

Exercise & Brain Energetics in PD

Who Can Participate

Age: 40Years - 80Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Diagnosis of idiopathic Parkinson's disease according to UK Brain Bank criteria
  • Mild to moderate Parkinsonism (Hoehn & Yahr stages I-III)
  • Currently exercising less than 120 minutes per week for non-exercisers
  • Age between 40 and 80 years
Not Eligible

You will not qualify if you...

  • Diagnosis of atypical Parkinson syndrome (e.g., progressive supranuclear palsy, multiple system atrophy, drug-induced)
  • Significant osteoporosis or arthritis
  • History of cancer within 5 years
  • High dose radiation exposure from other procedures within the past year
  • Unable to tolerate being off Parkinson's medication for up to 24 hours
  • Pregnancy or breastfeeding
  • Current or past substance use problems
  • Serious head injury with loss of consciousness for 5 minutes or more
  • Other chronic diseases such as diabetes, kidney problems, high blood pressure, other neurological disorders, or heart diseases
  • Significant respiratory disorders or use of home oxygen
  • Current or past neurological disorders other than Parkinson's disease
  • Current or past psychiatric disorders such as depression or anxiety
  • Severe claustrophobia
  • Weight over 158 kg (347 lbs)
  • Inability to lie still for up to 90 minutes
  • Not medically cleared to exercise
  • Certain medications or conditions affecting participation may exclude you based on individual discussion
  • MRI-specific exclusions including metal implants, pacemakers, ferromagnetic clips, implants, recent surgery or tattoos, and non-MRI safe devices
  • Significant cognitive impairment or depression after enrollment
  • Unstable cardiovascular or respiratory disease
  • Failure to complete at least 60 of 72 exercise classes during the intervention

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Pacific Parkinson's Research Centre

Vancouver, British Columbia, Canada, V6T 2B5

Actively Recruiting

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Research Team

J

Jessamyn McKenzie

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

BASIC_SCIENCE

Number of Arms

2

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