Actively Recruiting
Exercise and Carotid Artery Function in Metabolic Syndrome
Led by University of Wisconsin, Madison · Updated on 2026-03-25
48
Participants Needed
1
Research Sites
82 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to determine 1) if young adults with metabolic syndrome display endothelial dysfunction of the internal carotid artery in a sex-specific fashion and 2) if this endothelial dysfunction can be acutely improved with a single bout of exercise. This will be achieved by testing internal carotid artery function before and after a 30-minute bout of moderate intensity exercise. 48 young adults with and without metabolic syndrome will be enrolled and will be on study for approximately 5.5 hours over 4 study visits.
CONDITIONS
Official Title
Exercise and Carotid Artery Function in Metabolic Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- For metabolic syndrome group: waist circumference over 102 cm (males) or 82 cm (females)
- Triglycerides over 150 mg/dL
- HDL cholesterol less than 40 mg/dL (males) or 50 mg/dL (females)
- Blood pressure at least 130/85 mmHg
- Fasting plasma glucose over 110 mg/dL
- For healthy group: meet age criteria (18 to 40 years)
You will not qualify if you...
- Current smoker of more than 5 cigarettes in the past 30 days
- History or diagnosis of peripheral vascular, hepatic, renal, lung, gastrointestinal, hematologic diseases, stroke, heart attack, coronary heart disease, congestive heart failure, heart surgery, sleep apnea, autoimmune diseases, traumatic brain injury, concussion, seizures, asthma, or polycystic ovarian syndrome
- Type II diabetes
- Currently pregnant or breastfeeding
- Current musculoskeletal injury
- Use of medications affecting cardiovascular function except oral contraceptives
- Use of hormonal contraceptives like intrauterine devices or hormonal implants
- Unsuitable internal carotid arteries for imaging
- For healthy controls only: BMI over 25 kg/m2
- Blood pressure over 125/80 mmHg
- Meeting any metabolic syndrome criteria listed for metabolic syndrome group
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Wisconsin
Madison, Wisconsin, United States, 53792
Actively Recruiting
Research Team
S
Shawn Bolin, MS
CONTACT
L
Logan Heenan, BS
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here