Actively Recruiting
Exercise for Cognitive Excellence in Parkinson's Disease
Led by University of California, San Francisco · Updated on 2026-03-09
32
Participants Needed
1
Research Sites
175 weeks
Total Duration
On this page
Sponsors
U
University of California, San Francisco
Lead Sponsor
N
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study will evaluate the safety and feasibility of a home-based, virtually-supervised, combined high intensity endurance and resistance training program in people with Parkinson's disease. It will also evaluate the effects of exercise on cognition and underlying exercise-related biological markers (biomarkers).
CONDITIONS
Official Title
Exercise for Cognitive Excellence in Parkinson's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of idiopathic Parkinson's disease based on MDS criteria, including bradykinesia plus one other cardinal sign (resting tremor or rigidity), with no other known cause of parkinsonism
- Modified Hoehn and Yahr stage less than 4
- Age between 40 and 80 years at screening
- Stable doses of PD symptomatic medications for at least 2 months prior to baseline, or not currently treated but unlikely to require medication in the next 6 months
You will not qualify if you...
- Diagnosis of atypical parkinsonism, drug-induced parkinsonism, essential tremor, primary dystonia, or other non-PD causes of symptoms
- Significant neurological diseases other than PD that interfere with study procedures
- Significant cognitive impairment (MoCA score below 23) or impairment preventing exercise adherence
- Beck Depression Inventory II score above 16 indicating depression that prevents exercise
- Use of neuroleptics/dopamine receptor blockers for over 30 days in the past year or within 30 days before baseline
- Recent use of psychotropic medications without stable dosage for more than 30 days prior to screening
- Known cardiovascular, metabolic, or renal disease or symptoms without medical clearance for exercise
- Abnormal liver or renal function based on screening labs
- Complete Blood Count abnormalities deemed clinically significant
- Uncontrolled hypertension (resting blood pressure over 150/90 mmHg)
- Orthostatic hypotension with standing systolic blood pressure below 100 mmHg
- Already exercising 120 minutes or more per week at moderate intensity
- Serious illness requiring systemic treatment or hospitalization within the last 4 weeks
- Medical problems or injuries interfering with exercise ability
- Conditions preventing safe lumbar puncture (e.g., coagulopathy, low platelet count, infection at puncture site, recent anticoagulant use except low dose aspirin, suspected hydrocephalus or intracranial mass, spinal disease)
- Participation in another investigational study with intervention
- Use of non-PD investigational products within 30 days before baseline
- History of frequent falls or high fall risk
- Lack of access to computer/tablet and WiFi or other technical issues preventing virtual exercise participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of California San Francisco
San Francisco, California, United States, 94518
Actively Recruiting
Research Team
N
Nijee Luthra, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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