Actively Recruiting
Exercise and Dietary Lifestyle Intervention on Reducing Atrial Fibrillation Burden, Cardiac and Body Fat Mass.
Led by University of Eastern Finland · Updated on 2026-02-24
158
Participants Needed
4
Research Sites
165 weeks
Total Duration
On this page
Sponsors
U
University of Eastern Finland
Lead Sponsor
K
Kuopio University Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Atrial fibrillation (AF) is the most common cardiac arrhythmia and is strongly associated with obesity and excess body fat. Lifestyle interventions, including exercise and dietary modification, may reduce AF burden, but long-term randomized controlled trial evidence with objective AF burden assessment and advanced cardiac imaging is limited. The MOVE-AF trial is a randomized controlled trial designed to evaluate whether a 12-month tailored exercise and dietary lifestyle intervention, compared with usual care, reduces atrial fibrillation burden and symptom severity and decreases cardiac and total body fat mass in overweight and obese adults with paroxysmal or persistent AF.
CONDITIONS
Official Title
Exercise and Dietary Lifestyle Intervention on Reducing Atrial Fibrillation Burden, Cardiac and Body Fat Mass.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-75 years
- Body mass index (BMI) ≥27 kg/m²
- Documented paroxysmal or persistent atrial fibrillation
- Ability to participate in exercise training and follow study procedures
- Access to a smartphone or device for rhythm monitoring
- Provides written informed consent
You will not qualify if you...
- Permanent atrial fibrillation
- Unstable angina or acute coronary syndrome within the past 3 months
- Participation in other lifestyle or drug weight reduction trials
- Left ventricular ejection fraction below 30%
- Severe valvular heart disease or planned cardiac surgery
- Severe heart failure (NYHA class IV) or severe angina (CCS class IV)
- Unstable coronary artery disease or recent heart attack
- Severe lung disease limiting exercise
- Active cancer
- Autoimmune or systemic inflammatory diseases
- Severe kidney or liver failure
- Memory disease or significant cognitive impairment
- Unstable psychiatric condition
- Recent joint or back surgery within 6 months
- Ongoing back or joint pain preventing exercise
- Contraindications to exercise testing or training
- Pregnancy or breastfeeding
- Participation in another interventional study
- Any condition making participation unsafe or not possible
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Hospital Nova of Central Finland
Jyväskylä, Central Finland, Finland
Actively Recruiting
2
University of Eastern Finland
Kuopio, Eastern Finland, Finland
Not Yet Recruiting
3
Kuopio University Hospital
Kuopio, Northern Savonia, Finland
Not Yet Recruiting
4
Tampere University Hospital
Tampere, Finland
Not Yet Recruiting
Research Team
J
Jari Laukkanen, MD, PhD
CONTACT
M
Merja Perhonen, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here