Actively Recruiting
Intrahospital Exercise Program in Hemodialysis Patients Impact on Sarcopenia Markers, Sleep Quality, and Quality of Life.
Led by University of Salamanca · Updated on 2026-03-03
58
Participants Needed
1
Research Sites
25 weeks
Total Duration
On this page
Sponsors
U
University of Salamanca
Lead Sponsor
G
Gerencia Regional de Salud de Castilla y Leon
Collaborating Sponsor
AI-Summary
What this Trial Is About
Sarcopenia, which is the loss of muscle mass, strength, and function, is common in patients with Chronic Kidney Disease CKD who are undergoing hemodialysis. This condition increases the risks of falls, frailty, and death. Researchers are evaluating how a 12-week supervised exercise program during dialysis affects muscle mass, strength, physical performance, sleep quality, and overall quality of life in hemodialysis patients aged 40 years and older. Participants will be randomly assigned to one of two groups an Intervention Group that performs personalized strength and aerobic exercises during the first 30 minutes of their dialysis sessions three times a week for 12 weeks, and a Control Group that receives standard care without exercise. The exercise sessions are supervised by physiotherapists and include warm-up, strength training for lower limbs with equipment like elastic bands and weighted straps, and aerobic exercise using a bed-cycle ergometer with gradually increasing intensity. During the study, participants will be assessed at the start and after 12 weeks for changes in muscle strength using handgrip dynamometry and a sit-to-stand test, muscle mass using bioelectrical impedance, physical performance with the Short Physical Performance Battery, and sleep quality via the Pittsburgh Sleep Quality Index. Additional evaluations include sleep monitoring with wrist accelerometers and body composition. The study aims to see if integrating exercise into routine dialysis care can improve sarcopenia markers, sleep, and quality of life in this population.
CONDITIONS
Brief Title
Exercise During Hemodialysis: Impact on Sarcopenia and Sleep Quality
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Subjects currently enrolled in a Chronic Hemodialysis Unit.
- Patients who have been on hemodialysis treatment for more than 3 months.
- Subjects aged 40 years or older.
- Hemoglobin levels greater than 10 mg/dl.
- Ability to perform physical fitness assessment tests or dynamometry.
- Willingness and ability to provide signed informed consent
You will not qualify if you...
- Presence of intradialytic instability.
- Medical conditions where exercise is contraindicated: active infectious process, neoplasms, uncontrolled arrhythmias, or left ventricular dysfunction (EF < 35%).
- Musculoskeletal or respiratory alterations that worsen with exercise.
- Lower limb amputation without a prosthesis.
- Cerebrovascular disease (stroke with sequelae or transient ischemic attacks within the previous 6 weeks).
- Uncontrolled hypertension (Systolic BP > 200 mmHg or Diastolic BP > 120 mmHg).
- Unstable angina (at rest or during exercise) or history of coronary bypass/ischemic heart disease within the previous 6 weeks.
- Diabetes mellitus with severe decompensation (blood glucose > 300 mg/dl).
- Dialysis-related hypotension (mean blood pressure < 90/70 mmHg).
- Psychiatric or cognitive alterations that prevent collaboration with muscle training programs.
- Presence of an arteriovenous fistula in a lower limb.
- Motor neurological injury causing dysfunction that prevents the application of the strength protocol.
- Hospitalization within the 3 months prior to the study.
- Lack of cooperation (defined as failing to attend more than 25% of sessions) or inability to understand the treatment.
Research Team
M
María de la Luz Sánchez Tocino, PhD
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