Actively Recruiting

Phase Not Applicable
Age: 18Years - 64Years
All Genders
NCT06127342

Exercise and Emotional Learning in Posttraumatic Stress Disorder

Led by Christal L Badour · Updated on 2025-09-03

100

Participants Needed

2

Research Sites

133 weeks

Total Duration

On this page

Sponsors

C

Christal L Badour

Lead Sponsor

U

University of Texas at Austin

Collaborating Sponsor

AI-Summary

What this Trial Is About

The goal of this clinical trial is to test how exercise affects learning and memory processes relevant to the treatment of PTSD. Participants will complete a baseline intake followed by two experimental sessions. During the first experimental session, participants will undergo an MRI session of imaginal exposure to traumatic memory cues followed by 30-minutes of moderate intensity exercise or low intensity exercise. Participants will complete a second session of imaginal exposure with MRI 24 hours later.

CONDITIONS

Official Title

Exercise and Emotional Learning in Posttraumatic Stress Disorder

Who Can Participate

Age: 18Years - 64Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Adults with PTSD related to interpersonal violence
Not Eligible

You will not qualify if you...

  • Active or recent (within the last 3 months) severe substance use disorder(s)
  • Active or recent (within the last 3 months) suicidal, psychotic, or manic symptoms/ episodes
  • Significant developmental disabilities
  • Current daily benzodiazepine or stimulant use with inability to abstain for study sessions
  • Recent changes in psychiatric medication or trauma focused cognitive-behavioral therapy (CBT) (past 4-weeks)
  • Medical condition(s) that prohibit exercise
  • History of traumatic brain injury (TBI) with loss of consciousness > 30 mins
  • Magnetic resonance imaging (MRI) contraindication(s)
  • Positive pregnancy test
  • History of seizure disorder
  • Spontaneous seizure(s) within the last 3 months

AI-Screening

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Trial Site Locations

Total: 2 locations

1

University of Kentucky

Lexington, Kentucky, United States, 40506

Actively Recruiting

2

University of Texas

Austin, Texas, United States, 78712

Actively Recruiting

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Research Team

C

Christal G Badour, PhD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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Exercise and Emotional Learning in Posttraumatic Stress Disorder | DecenTrialz