Exercise to enhance cardiovascular health among black men with prostate cancer with androgen deprivation therapy (the POWER trial): A study protocol.
Dong-Woo Kang, Salvatore Ficarra, Rebekah L Wilson...
https://pubmed.ncbi.nlm.nih.gov/40451460/Actively Recruiting
Led by Dana-Farber Cancer Institute · Updated on 2026-07-29
62
Participants Needed
1
Research Sites
21 weeks
Total Duration
This research focuses on Black men diagnosed with prostate cancer who are undergoing androgen deprivation therapy ADT. It aims to evaluate whether a 16-week culturally tailored exercise program, combining aerobic and resistance training, can improve cardiovascular risk factors, physical fitness, body composition, quality of life, cancer symptoms, and self-esteem. Participants are randomly assigned to either the exercise program or usual care. The exercise group takes part in a virtually supervised program performed at home via Zoom, exercising three times per week for 16 weeks under professional supervision. The usual care group maintains their baseline exercise levels for 16 weeks and is offered the exercise program after the study. Participants undergo testing visits at study start and after 16 weeks, with the exercise group having an additional mid-study fitness assessment at week 8. During the study, participants provide blood samples and have their body composition, cardiorespiratory fitness, muscular strength, and other health measures assessed through surveys and physical tests. Researchers monitor cardiovascular disease risk factors and various secondary outcomes such as physical performance, body fat, quality of life, cancer symptoms, and self-esteem. The total participation time is approximately 4 months.
CONDITIONS
Exercise to Enhance Cardiovascular Health Among Black Prostate Cancer Patients With Androgen Deprivation Therapy
C
Christina Dieli-Conwright, PhD, MPH
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Dana-Farber Cancer Institute
Lead Sponsor
Pfizer
Collaborating Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | Virtually supervised home‑based aerobic and resistance exercise (3×/week for 16 weeks) | Maintain baseline exercise; offered program after 16 weeks |
|---|---|---|
| What it is | A program of aerobic and resistance exercise performed at home with virtual supervision, three times weekly for 16 weeks | Continuing usual baseline activity levels for 16 weeks, with the exercise program offered afterward |
| Role in the trial | Experimental intervention arm delivering exercise support | Active comparator arm reflecting current activity without structured added exercise |
| Trial purpose | Evaluate if structured at‑home supervised exercise improves cardiovascular risk factors in men on ADT | Provide control arm to compare against exercise intervention effects |
| How it is given or performed | Virtually supervised sessions at home combining aerobic activity (such as cycling) and resistance training (dumbbells or bands), three times per week | No new exercise structure, maintain usual activity for study duration, with program offered after 16 weeks |
| Current evidence beyond this trial | Exercise combining aerobic and resistance training has shown benefits on physical function, cardiovascular risk factors, fatigue and quality of life in men receiving ADT | Lack of structured exercise may contribute to worsening cardiovascular risk and functional decline during ADT |
| Important risks | Not characterized within trial; general exercise risks may include musculoskeletal strain depending on individual health | No structured intervention, risk related to inactivity such as cardiovascular deconditioning |
| Important limitations | Evidence on optimal exercise dose, modality, and long‑term adherence remains limited | May not reflect standard activity patterns in broader populations; lack of structured control limits understanding of minimal activity effects |
| Patient‑relevant outcomes | Combined exercise has improved quality of life, strength, fat mass and fatigue in men on ADT | Maintaining usual activity may result in continued fatigue, muscle loss, and reduced quality of life |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 16 weeks
Participants are randomly assigned to either a virtually supervised aerobic and resistance exercise program performed at home three times per week for 16 weeks or to usual care maintaining their baseline exercise levels.
Testing visits at study start, week 8 (exercise group only), and end of study
Duration - At study completion (4 months total participation)
Researchers assess changes in cardiovascular risk factors, physical fitness, body composition, and quality of life using blood tests, physical tests, and surveys.
2 testing visits for all participants; 1 additional visit at week 8 for the exercise group
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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Dong-Woo Kang, Salvatore Ficarra, Rebekah L Wilson...
https://pubmed.ncbi.nlm.nih.gov/40451460/Dana-Farber Cancer Institute
Lead Sponsor
Pfizer
Collaborating Sponsor