Actively Recruiting
Exercise Facilitation of Adolescent Fear Extinction, Frontolimbic Circuitry, and Endocannabinoids
Led by Wayne State University · Updated on 2025-08-07
174
Participants Needed
1
Research Sites
206 weeks
Total Duration
On this page
Sponsors
W
Wayne State University
Lead Sponsor
N
National Institute of Mental Health (NIMH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Anxiety disorders commonly begin during adolescence, and are characterized by deficits in the ability to inhibit or extinguish pathological fear. Recent research has provided new understanding of how fear is learned and can be regulated in the adolescent brain, and how the endocannabinoid system shapes these processes; however, these advances have not yet translated into improved therapeutic outcomes for adolescents with anxiety. This study will test whether a behavioral intervention, acute exercise, can help to improve fear regulation by enhancing brain activity and endocannabinoid signaling. This line of research may ultimately lead to more effect treatments for adolescent anxiety, and to new preventive strategies for at-risk youth.
CONDITIONS
Official Title
Exercise Facilitation of Adolescent Fear Extinction, Frontolimbic Circuitry, and Endocannabinoids
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed and dated informed consent form
- Willingness to comply with all study procedures and available for the study duration
- Age between 14 and 17 years at enrollment
- Right-handed
- Good general health based on medical history
- Adolescent and parent/guardian are English-speaking
- Availability of a parent or legal guardian to provide consent and attend all visits
You will not qualify if you...
- Traumatic brain injury with ongoing symptoms
- Sensory or physical impairment or significant developmental delay
- MRI contraindications such as braces, implants, or claustrophobia
- Conditions contraindicating blood draws like hemophilia or sickle cell
- Past or current neurological disorders, psychotic disorders, or bipolar disorder
- Severe or unstable medical conditions such as diabetes or rheumatoid arthritis
- Use of cannabis or cannabinoid products including CBD in the past month unless willing to stop 4 weeks before study
- Currently pregnant, lactating, or positive pregnancy test
- Current homicidal thoughts or suicide attempt within the past year
- Current suicidal thoughts needing immediate intervention
- Use of oral contraceptives in the past 6 weeks
- Diagnosed or probable substance use disorder in the past month
- Positive drug test at baseline
- Moderate to severe drug or alcohol use in the past 8 weeks
- Recent COVID-19 diagnosis or febrile illness in the past month
- Treatment with investigational drug or intervention in the past month
- Current use of tobacco, nicotine, or vaping products in the past month
- Ongoing exposure to abuse
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Tolan Park Medical Building
Detroit, Michigan, United States, 48201
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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