Actively Recruiting
Exercise for Gut Microbiome in Patients With Young-Onset Colorectal Cancer Undergoing Chemotherapy: The COURAGE Trial
Led by Dana-Farber Cancer Institute · Updated on 2025-08-15
84
Participants Needed
1
Research Sites
157 weeks
Total Duration
On this page
Sponsors
D
Dana-Farber Cancer Institute
Lead Sponsor
A
American Cancer Society, Inc.
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research study is a randomized controlled trial that will observe changes in microbiome activity, changes in chemotherapy toxicity, and any changes in treatment outcomes between two groups of participants undergoing chemotherapy with either early-stage or metastatic colorectal cancer. The names of the study groups involved in this study are: * Exercise * Waitlist Control
CONDITIONS
Official Title
Exercise for Gut Microbiome in Patients With Young-Onset Colorectal Cancer Undergoing Chemotherapy: The COURAGE Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with early-stage or metastatic colon or rectal cancer
- Age between 18 and 50 years at diagnosis
- No major surgery planned for at least 12 weeks during the study (port a cath placement allowed)
- No radiation therapy planned for at least 12 weeks during the study
- Currently on or planning to start chemotherapy
- Engages in 90 minutes or less of moderate-to-vigorous exercise per week
- Medical clearance from oncologist to perform exercise and testing
- No uncontrolled medical conditions that could worsen with exercise
- Able to communicate and complete written forms in English
- Willing to sign informed consent before study procedures
- Willing to travel to Dana-Farber Cancer Institute for data collection
You will not qualify if you...
- Engages in more than 90 minutes of moderate-to-vigorous aerobic exercise per week in the past month
- Has unstable medical conditions that prevent safe participation in moderate-to-vigorous exercise
- Currently on a weight loss diet or taking weight loss drugs
- Has other active cancers (except basal cell carcinoma)
- Unable to comply with safety monitoring requirements of the study as judged by the investigator
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Dana Farber Cancer Institute
Boston, Massachusetts, United States, 02215
Actively Recruiting
Research Team
C
Christina Dieli-Conwright, MPH, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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