Actively Recruiting
Exercise, Gut Microbiota and Type 2 Diabetes
Led by University of Thessaly · Updated on 2025-03-28
60
Participants Needed
1
Research Sites
63 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This randomized, parallel, controlled study, will investigate the effect of regular exercise on GM composition, inflammatory status, and insulin sensitivity, in the progression from normal glucose tolerance (NGT), to prediabetes (pre-D), to type 2 diabetes (T2D). Following baseline assessment of glucose tolerance, the participants will be randomly assigned to either a 12-week, thrice-weekly exercise training program followed by 4 weeks of detraining, or will remain sedentary for the 16-week intervention. Thus, the six study groups will be: 1) NGT group (NGT), NGT individuals - no exercise, 2) NGT exercise group (NGT+Ex), NGT individuals that will participate in training and detraining, 3) pre-D group (pre-D), pre-D individuals - no exercise, 4) pre-D exercise group (Pre-D+Ex), pre-D individuals that will participate in training and detraining, 5) T2D group (T2D), T2D individuals - no exercise, and 6) T2D exercise group (T2D+Ex), T2D individuals that will participate in training and detraining. Assessment of physiological measures, anthropometric characteristics, body composition, glucose tolerance, insulin sensitivity, complete blood count, lipidemic profile, GM composition, inflammatory status, oxidative stress, and muscle performance, will be conducted before and following 12 weeks of the exercise training intervention and following 4 weeks of detraining for all participants.
CONDITIONS
Official Title
Exercise, Gut Microbiota and Type 2 Diabetes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 45 and 65 years old
- Sedentary lifestyle or insufficient daily physical activity according to guidelines for T2D
- No use of anti-inflammatory drugs, antibiotics, or dietary supplements affecting gut microbiota for more than 3 months before the study
- No chronic diseases or musculoskeletal injuries within the past 6 months
You will not qualify if you...
- Age under 45 years or over 65 years
- Physically active individuals
- Use of anti-inflammatory drugs, antibiotics, or dietary supplements affecting gut microbiota within 3 months before the study
- Presence of other chronic diseases or musculoskeletal injury within the last 6 months
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Department of Physical Education and Sport Science, Uninersity of Thessaly
Trikala, Greece, 42100
Actively Recruiting
Research Team
C
Chariklia K. Deli, PhD
CONTACT
A
Athanasios Z Jamurtas, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SCREENING
Number of Arms
6
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