Effects of a 12-week Exercise Intervention on Physical and Mental Health in Hereditary ATTR ATTRv Amyloidosis

What this Trial Is About

Researchers are investigating the effects of a 12-week exercise program on both the physical and mental health of people living with Hereditary ATTR ATTRv Amyloidosis, a rare genetic disease caused by mutations in the transthyretin gene that lead to amyloid deposits in nerves and organs. This study seeks to expand knowledge in this area, especially among patients receiving new therapies, and aims to explore the potential mental health benefits of exercise alongside physical improvements. It also aims to raise awareness about the importance of an active lifestyle for improving quality of life in this community. Participants will be randomly assigned to one of two groups one group will take part in a supervised exercise program lasting 12 weeks, while the other group will not participate in the exercise intervention. The exercise program includes sessions three times a week, each lasting 60 minutes, with gradually increasing intensity monitored by a perceived exertion scale. Exercises focus on cardiorespiratory fitness, resistance training, flexibility, and neuromotor skills such as balance, coordination, and gait. Activities like tai ji and yoga are also included to support overall motor skills and joint mobility. Throughout the study, participants will undergo assessments at the start and immediately after the 12-week period. These assessments measure physical outcomes like knee extensor strength, grip strength, walking capacity, body mass index, weight, fat-free mass, fat mass, and body water. Mental health will also be evaluated to understand the psychological impact of the exercise program. The total participation time covers the 12-week exercise intervention and the corresponding assessments to monitor changes in health and wellbeing.

Exercise in Hereditary ATTR (ATTRv) Amyloidosis