Exercise and Drug Effects on Immune Cells for Blood Cancer Cell Therapy Early Phase 1 Study Testing Exercise and Beta Blockers in Healthy Donors

What this Trial Is About

Researchers are exploring ways to improve blood cancer treatment by using exercise to collect healthier immune cells from donors. This trial focuses on allogeneic adoptive cell therapy, where immune cells from healthy donors are given to cancer patients to prevent or treat relapse after stem cell transplant. The study aims to enhance the therapys effectiveness and reduce side effects like graft-versus-host disease GvHD, where donor cells attack the patients healthy tissues. The trial includes three groups one where participants complete a 20-minute cycling exercise and provide blood samples before, during, and after another where participants take either a placebo or beta blocker drugs before exercise sessions to study hormone effects on immune cells and a third where participants receive a 20-minute infusion of isoproterenol, a drug that mimics adrenaline, with blood samples collected similarly. Participants can join one, two, or all groups. Participants will undergo various assessments including exercise tests, blood sampling, and monitoring by cardiologists. Blood samples will be analyzed to count and study immune cells, test their ability to kill cancer cells in the lab, and observe effects on tumor growth in mice. The study also measures clinical outcomes like tumor burden, survival, and GvHD scores over up to 120 days. The goal is to understand how exercise and related treatments can improve immune cell therapies for blood cancers.

Exercise as an Immune Adjuvant for Allogeneic Cell Therapies