Exercise Training for Adults with Non-obstructive Hypertrophic Cardiomyopathy to Improve Symptoms and Heart Function

What this Trial Is About

Researchers are studying adults aged 18 to 80 with hypertrophic cardiomyopathy HCM to compare the effects of moderate intensity exercise training against usual physical activity. This trial aims to evaluate how these approaches impact symptoms related to HCM and heart function over 24 weeks. Approximately 70 participants will be randomly assigned to either an exercise group or a usual activity group for this randomized, controlled, and single-blinded study. Participants assigned to the exercise group will begin with a supervised session and consultation with an exercise physiologist in a hospital setting. Afterward, they will continue exercise sessions at home with video supervision three times per week for 24 weeks. Those in the usual activity group will maintain their current physical activity levels without starting or increasing exercise during the study period. Throughout the 24 weeks, participants will undergo various assessments including physical exams, questionnaires, 12-lead ECGs, biomarker testing, echocardiograms, cardiac MRI, PET scans, and cardiopulmonary exercise testing. Researchers will measure changes in maximum oxygen uptake VO2 max and heart muscle function to monitor response to the interventions. Safety and adherence will be tracked, and the study will conclude after the 24-week follow-up period.

Exercise Intolerance in Non-obstructive Hypertrophic Cardiomyopathy