Actively Recruiting
Exercise Intolerance in Non-obstructive Hypertrophic Cardiomyopathy
Led by University of California, San Francisco · Updated on 2025-11-20
70
Participants Needed
1
Research Sites
210 weeks
Total Duration
On this page
Sponsors
U
University of California, San Francisco
Lead Sponsor
N
National Institutes of Health (NIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The EXCITE-HCM study is a randomized, controlled, blinded clinical trial designed to evaluate the effect of moderate intensity exercise training versus usual physicial activity on the improvement of HCM-related symptoms and cardiac function. About 70 participants will be recruited and randomized on a 1:1 ratio to either moderate intensity training or usual physicial activity interventions. Patients will be followed during a period of 24 weeks and assesesments as physical examination, questionnaires, 12 lead ecg's, biomarker levels, echocardiogram, Cardiac Magnetic resonance, PET and CPET will be performed to evaluate their response to the intervention.
CONDITIONS
Official Title
Exercise Intolerance in Non-obstructive Hypertrophic Cardiomyopathy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients 18 to 80 years of age with hypertrophic cardiomyopathy defined by left ventricular hypertrophy of 15 mm or greater or 13 to 15 mm with other suggestive features
- Left ventricular outflow tract gradient less than 30 mmHg at rest and with provocation
- Left ventricular ejection fraction of 50% or greater by echocardiography
- Access to exercise equipment at home or a fitness center
- Ability to complete study tests including online surveys and smartphone use
- Ability to perform 24 weeks of exercise training
You will not qualify if you...
- History of exercise-induced fainting or dangerous heart rhythms
- Being evaluated for septal reduction therapy with less than 3 months since evaluation
- History of septal reduction therapy by surgery or ablation
- History of implantable cardioverter-defibrillator placement in the past 3 months
- History of large drops in blood pressure during exercise testing
- Clinical deterioration in the past 3 months with severe heart failure or angina symptoms
- Left ventricular ejection fraction less than 50%
- Life expectancy less than 12 months
- Pregnancy or planned pregnancy
- Inability to exercise due to medical or other reasons
- Unwillingness to avoid competitive sports, burst activity, or heavy isometric exercise if assigned to non-exercise group
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of California - San Francisco
San Francisco, California, United States, 94143
Actively Recruiting
Research Team
C
Cynthia Partida-Higuera, CCRP
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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