Actively Recruiting
Exercise in Metastatic Breast Cancer: EMBody
Led by Indiana University · Updated on 2026-04-27
100
Participants Needed
6
Research Sites
240 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to study exercise in a novel population with indolent MBC (no progression on current therapy in prior 12 months and not receiving cytotoxic chemotherapy). The study team hypothesizes that delivering virtual, supervised, progressive intensity aerobic and resistance training exercise for 16 weeks in this population will significantly improve 1) cardiorespiratory fitness, functional status, and sarcopenia (low muscle mass), all established predictors of survival, and 2) patient- reported outcomes.
CONDITIONS
Official Title
Exercise in Metastatic Breast Cancer: EMBody
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Diagnosis of metastatic breast cancer
- No disease progression in the 12 months before screening
- ECOG performance status between 0 and 2
- Ability to walk on a treadmill without an assistive device
- Informed consent and authorization for health information release
- Currently exercising less than 150 minutes per week of moderate to vigorous activity
- Access to a cellular device compatible with iOS 15 or Android 7 or higher
You will not qualify if you...
- Receiving cytotoxic chemotherapy in the past 12 months
- Conditions preventing supervised exercise participation unless a physician letter supports participation, including:
- NYHA class III or IV congestive heart failure
- Uncontrolled angina
- Myocardial infarction within the past 12 months
- Orthopedic surgery in the past 3 months or planned during the study
- Chronic uncontrolled pulmonary conditions like asthma with symptoms more than 2 days per week or oxygen requirement
- Symptomatic peripheral vascular disease
- Other comorbidities interfering with study compliance, including psychological illness
- History of fragility fracture
- Active, untreated brain metastases
AI-Screening
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Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 6 locations
1
Yale Cancer Center
New Haven, Connecticut, United States, 06510
Completed
2
IU Health West
Avon, Indiana, United States, 46123
Withdrawn
3
IU Health Joe and Shelly Schwarz Cancer Center
Carmel, Indiana, United States, 46032
Withdrawn
4
Indiana University Melvin & Bren Simon Cancer Center
Indianapolis, Indiana, United States, 46202
Actively Recruiting
5
Sidney and Lois Eskenazi Hospital
Indianapolis, Indiana, United States, 46202
Withdrawn
6
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02215
Actively Recruiting
Research Team
N
Niraj Shah
CONTACT
T
Tarah Ballinger, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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