Actively Recruiting
Exercise and Monitoring With Post-Hospitalization Muscle Atrophy to Sustain Intrinsic Capacity and Strength
Led by VA Office of Research and Development · Updated on 2026-04-07
250
Participants Needed
2
Research Sites
233 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aging Veteran population has more frequent inpatient hospitalization than non-Veterans. In addition, older Veterans have an inability to fully recover muscle mass and function after hospital-acquired weakness. The problem of hospital-acquired weakness is greatly increased in at-risk Veteran populations such as those with chronic kidney disease (CKD). The purpose of this collaborative study involving Denver and Baltimore VAMC sites is to improve health through the detection and rehabilitation management of hospital-acquired weakness in those with CKD. The study goals include identifying and monitoring the optimal muscle assessment sites in clinical settings, examining how muscle health impacts length of hospital stay and physical resilience, and determining how home-based and supervised exercise comparatively addresses post-hospitalization physical resilience using performance tests and Veteran feedback.
CONDITIONS
Official Title
Exercise and Monitoring With Post-Hospitalization Muscle Atrophy to Sustain Intrinsic Capacity and Strength
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age > 55 years
- Diagnosis of stage 3-4 chronic kidney disease or an eGFR of <45 mL/min/1.73m2
You will not qualify if you...
- Poorly controlled hypertension (>160/100)
- Coronary event in past 6 months
- Class III or IV congestive heart failure
- Symptomatic angina at rest or during exercise
- Syncope in past year without known resolution
- Chronic obstructive pulmonary disease requiring home oxygen
- Contraindications to resistance training including history of intracranial or retinal bleeding
- Diabetes with active proliferative retinopathy
- History of significant spinal osteoarthritis or spinal stenosis
- Dementia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Rocky Mountain Regional VA Medical Center, Aurora, CO
Aurora, Colorado, United States, 80045-7211
Actively Recruiting
2
Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD
Baltimore, Maryland, United States, 21201
Actively Recruiting
Research Team
M
Michael Harris-Love, DSc MPT BS
CONTACT
K
Katie Boncella, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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