Cardiac rehabilitation in the paediatric Fontan population: development of a home-based high-intensity interval training programme.
Michael Khoury, Devin B Phillips, Peter W Wood...
https://pubmed.ncbi.nlm.nih.gov/32716280Actively Recruiting
Age: 10Years - 18Years
All Genders
ID06325280
Utilizing Exercise Cardiovascular and Skeletal Magnetic Resonance Imaging to Evaluate Factors Associated With Cardiorespiratory Fitness in Children With Acquired and Congenital Heart Disease
Led by University of Alberta · Updated on 2026-03-16
20
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating how the heart and skeletal muscles work together during exercise in children aged 10 to 18 years with acquired or congenital heart disease, including heart transplant recipients. The study aims to understand cardiac adaptations to exercise and their relationship to cardiorespiratory fitness using advanced imaging techniques. It also explores the effects of a 12-week high-intensity interval training program on heart and muscle function in this population. Participants will undergo cardiopulmonary exercise testing on a cycle ergometer to measure oxygen consumption and other fitness parameters. They will also have a standard cardiac MRI to evaluate heart structure and function at rest, followed by an exercise cardiac MRI using a stepping ergometer to assess heart and skeletal muscle function during activity. Questionnaires about feelings toward exercise will be completed by participants and their parents. Throughout the study, researchers will collect data on heart and muscle responses to exercise using MRI and exercise tests. They will analyze the relationships between these measures and fitness levels. The study will include about 20 participants and involve multiple assessments, including baseline and post-intervention evaluations. Safety, functionality, and participant experiences will be monitored, with the total study period lasting up to several months.
CONDITIONS
Brief Title
Exercise MRI to Evaluate Cardiorespiratory Fitness in Children With Heart Disease
Who Can Participate
Age: 10Years - 18Years
All Genders
Eligibility Criteria
You may qualify if you...
- Age between 10 and 18 years
- Followed at the Stollery Children's Hospital
- Heart transplant recipient at least 6 months post-transplant
- Diagnosis of moderate-complex congenital heart disease
You will not qualify if you...
- Non-English speaking
- Exercise restricted by the patient's clinical cardiologist
- Clinical antibody- or cellular-mediated rejection within 3 months of assessment or during study (for heart transplant recipients)
- Previous participation in a cardiac rehabilitation or exercise intervention program
- Previous exercise stress test showing sustained arrhythmias, significant ST segment changes, inappropriate blood pressure response, chest pain, or syncope
- Resting arterial oxygen saturation below 85% or oxygen requirement
- Moderate or worse ventricular systolic dysfunction on recent echocardiogram
- History of chest pain on exertion or unrepaired/unpalliated congenital heart disease
- Arrhythmias in the last year including supraventricular tachycardia, ventricular tachycardia, atrioventricular block (Mobitz II or worse)
- New York Heart Association class II or worse symptoms
- Active medical illness limiting participation
- Cognitive impairment limiting communication for exercise MRI
- Contraindications to MRI such as pacemakers or orthopedic limitations preventing exercise testing
- Extracardiac or congenital abnormalities limiting ability to exercise
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - Within 2 weeks
Participants complete cardiopulmonary exercise testing and undergo standard and exercise cardiac MRI assessments to evaluate cardiac and skeletal muscle function.
2 visits (in-person)
Trial Site Locations
Total: 1 location
1
University of Alberta
Edmonton, Alberta, Canada, T6G 2B7
Actively Recruiting
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Research Team
R
Rae Foshaug
M
Michael Khoury, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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Published Research Related To This Trial
Exploring the Promise of Telemedicine Exercise Interventions in Children and Adolescents With Congenital Heart Disease.
Christopher Spence, Nee Khoo, Andrew Mackie...
https://pubmed.ncbi.nlm.nih.gov/37657493Evaluating a Telemedicine Video Game-Linked High-Intensity Interval Training Exercise Programme in Paediatric Heart Transplant Recipients.
Christopher M Spence, Rae Foshaug, Samira Rowland...
https://pubmed.ncbi.nlm.nih.gov/37969861