Actively Recruiting
Exercise MRI to Evaluate Cardiorespiratory Fitness in Children With Heart Disease
Led by University of Alberta · Updated on 2026-03-16
20
Participants Needed
1
Research Sites
153 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
There are many barriers to heart-healthy lifestyles in pediatric patients with acquired and congenital heart disease. Investigators want to further understand how participants heart and skeletal muscles work together during exercise and evaluate the impact on cardiac function. To do this, the investigators will use magnetic resonance imaging (MRI) to scan the heart and skeletal muscles during exercises to assess blood flow, oxygenation and function.
CONDITIONS
Official Title
Exercise MRI to Evaluate Cardiorespiratory Fitness in Children With Heart Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 10 to 18 years and followed at the Stollery Children's Hospital
- Heart transplant recipients at least 6 months post-transplant
- Diagnosis of moderate-complex congenital heart disease
You will not qualify if you...
- Non-English speaking
- Exercise restricted by patient's clinical cardiologist
- Clinical antibody- or cellular-mediated rejection within 3 months of assessment or during study (for heart transplant recipients)
- Previous participation in cardiac rehabilitation or exercise intervention programs
- Previous exercise stress test showing sustained arrhythmias, significant ST changes, abnormal blood pressure response, or chest pain/syncope
- Resting arterial oxygen saturation below 85% or oxygen requirement
- Moderate or worse ventricular systolic dysfunction on recent echocardiogram
- History of chest pain on exertion or unrepaired/unpalliated congenital heart disease
- Arrhythmias in the last year including supraventricular tachycardia, ventricular tachycardia, atrioventricular block (Mobitz II or worse)
- New York Heart Association class II or worse symptoms
- Active medical illness limiting participation
- Cognitive impairment affecting communication for exercise MRI
- MRI contraindications such as pacemaker or orthopedic limitations preventing exercise
- Extracardiac or congenital abnormalities limiting exercise ability
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Alberta
Edmonton, Alberta, Canada, T6G 2B7
Actively Recruiting
Research Team
R
Rae Foshaug
CONTACT
M
Michael Khoury, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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