Actively Recruiting
Exercise Neuroprotection in Parkinson's Disease
Led by University of Nevada, Las Vegas · Updated on 2024-09-03
90
Participants Needed
1
Research Sites
121 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to explore the relationships of exercise on inflammation in the body of older adults and people with Parkinson's disease (PD). This is important research for older adults but is especially important for people with PD because neuroinflammation is the main pathological mechanism that is responsible for neuron cell death in this neurodegenerative disease. As PD is a progressive disease, halting or slowing the degeneration is an important research target. Halting or slowing the disease progress is known as neuroprotection. Exercise is an attractive therapeutic treatment for people with PD as it has a lot of multi-systemic benefits, but also there is a lot of evidence to suggest that it helps improve symptoms and slow the progression of the disease. Exercise has been theorized to decrease inflammation and, therefore, has a lot of promise as a neuroprotective agent in slowing or halting the degeneration in PD. Unfortunately, there is not a lot of research that has looked into the effect of exercise on the biological processes of inflammation. Thus, the purpose of this study is to investigate the biological evidence that underlies the positive effect of exercise in people with PD.
CONDITIONS
Official Title
Exercise Neuroprotection in Parkinson's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 30 and 85 years
- Parkinson's disease diagnosed by a neurologist (for PD group)
- Able to do 30 minutes of continuous moderate aerobic exercise with 2-3 short breaks (self-reported)
- No major medical diagnoses (for control group)
- Able to do 30 minutes of continuous moderate aerobic exercise with 2-3 short breaks (self-reported)
You will not qualify if you...
- Medical conditions that prevent exercise, such as heart arrhythmias, uncontrolled blood pressure, or exercise-induced asthma
- Not cleared for exercise participation based on Physical Activities Readiness Questionnaire + screening
- Dementia, defined by a Montreal Cognitive Assessment score at or below 21
- Inability to complete self-report questionnaires due to cognitive impairment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Gait and Balance Laboratory, 217 Bigelow Health Sciences Building, UNLV
Las Vegas, Nevada, United States, 89154
Actively Recruiting
Research Team
M
Merrill Landers, DPT, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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