Actively Recruiting
Exercise Physiology in Patients With Aortic Aneurysm and Its Correlation With Mechanical Properties of Aortic Tissue
Led by The Cleveland Clinic · Updated on 2026-01-02
35
Participants Needed
1
Research Sites
279 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Aortic aneurysm patients benefit from exercise yet patients and physicians do not know a safe level. Cardiac MRI (CMR) is the most comprehensive imaging modality for phenotypic evaluation of patients with cardiac disease but it has not been used to study aneurysm patients. The purpose of this project is use exercise CMR to understand regional aortic function and quantify aortic elasticity in these populations while exercising. This project will correlate the exercise CMR data with the biomechanical properties of the patient's aortic tissue, including epiaortic ultrasound and TEE performed during aortic repair, and explanted aortic specimens subjected to ex vivo uniaxial tensile testing. Correlating this data with aortic response to exercise will allow us to understand how aortic size, in vivo circumferential strain values, ex vivo aortic efficiency and mechanical failure all relate to exercise physiology.
CONDITIONS
Official Title
Exercise Physiology in Patients With Aortic Aneurysm and Its Correlation With Mechanical Properties of Aortic Tissue
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy controls aged 18 years or older with no history of cardiovascular disease, hypertension, diabetes, or high cholesterol
- Aneurysm patients aged 18 years or older who have not had surgery for aortic aneurysm
- Pre-operative aneurysm patients admitted for elective aortic aneurysm surgery, aged 18 years or older
- Pre-operative aneurysm patients who will be imaged before surgery and at 12 months post-surgery
You will not qualify if you...
- Any contraindication to MRI, including having a pacemaker, defibrillator, cochlear implant, implanted drug pump, programmable shunt, aneurysm clips, stents outside the heart, blood clot filters, or metal fragments in the body
- Congenital heart diseases such as patent ductus arteriosus, coarctation of the aorta, atrial septal defect, or ventricular septal defect
- Presence of arteriovenous fistula or intracardiac shunts
- Moderate or severe dysfunction in multiple heart valves
- Significant claustrophobia or inability to tolerate MRI
- Inability to pedal a supine bicycle
- Requirement for supplemental oxygen
- Healthy controls using cardioprotective medication or diagnosed with bicuspid aortic valve
- Pre-operative aneurysm patients with traumatic aortic rupture
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Actively Recruiting
Research Team
J
Jonathan Putnam
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
3
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