Actively Recruiting
Exercise Physiology in Patients With Aortic Aneurysm and Its Correlation With Mechanical Properties of Aortic Tissue
Led by The Cleveland Clinic · Updated on 2026-01-02
35
Participants Needed
1
Research Sites
12 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating how exercise affects patients with aortic aneurysms, a condition where the aorta is enlarged and at risk of complications. The study uses exercise cardiac MRI (CMR), an advanced imaging method, to assess how the aorta functions during exercise. The goal is to understand the relationship between aortic size, elasticity, and mechanical properties with exercise stress, which could help determine safe exercise levels for these patients. Participants include healthy controls, aneurysm patients being monitored, and pre-operative aneurysm patients scheduled for surgery. All groups undergo exercise MRI using an MRI-compatible exercise ergometer to measure blood flow, aortic compliance, distensibility, and other detailed heart and aorta function parameters during exercise. Pre-operative patients are imaged before surgery and again after 12 months. Participants will be involved in exercise MRI scanning sessions where their aortic function is measured under stress. Researchers will analyze arterial compliance over up to 12 months and correlate imaging data with tissue properties obtained during surgery from explanted aortic samples. The study includes safety screening for MRI compatibility and monitoring of exercise tolerance. The total involvement duration varies based on participant group and timing of follow-up imaging.
CONDITIONS
Brief Title
Exercise Physiology in Patients With Aortic Aneurysm and Its Correlation With Mechanical Properties of Aortic Tissue
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy controls must be 18 years or older with no history of cardiovascular disease, hypertension, diabetes, or high cholesterol
- Aneurysm patients being monitored must be 18 years or older and have no history of aortic aneurysm surgery
- Pre-operative aneurysm patients must be 18 years or older and admitted for elective surgery due to aortic aneurysm
You will not qualify if you...
- Contraindications for MRI including having a pacemaker, defibrillator, implanted stimulators or devices, cochlear implants, drug pumps, programmable shunts, aneurysm clips, coils, stents outside the heart, blood clot filters, or metal fragments in the body or eye
- Congenital heart diseases such as patent ductus arteriosus, coarctation of aorta, ASD, or VSD
- Presence of A-V fistula or intracardiac shunts
- Moderate or severe dysfunction in multiple heart valves
- Significant claustrophobia
- Inability to pedal a supine bicycle
- Requirement for supplemental oxygen
- Healthy controls using cardioprotective medication
- Healthy controls with bicuspid aortic valve diagnosed by MRI
- Pre-operative aneurysm patients with traumatic aortic rupture
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 12 months
Participants undergo exercise stress MRI with an MRI compatible exercise ergometer to assess aortic blood flow and mechanical properties under exercise conditions.
1 to 3 visits depending on participant group and follow-up schedule
Trial Site Locations
Total: 1 location
1
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Actively Recruiting
Research Team
J
Jonathan Putnam
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
3
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