Actively Recruiting
Exercise as a Primer for Brain Stimulation in Vascular Cognitive Impairment No Dementia (VCIND)
Led by Sunnybrook Health Sciences Centre · Updated on 2026-04-13
64
Participants Needed
1
Research Sites
262 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
People with vascular conditions are at risk of having memory problems, and these memory problems increase the risk for further cognitive decline. Brain stimulation has been used to improve mood and memory. Transcranial direct current stimulation (tDCS) is believed to work best on brain cells that are active or "primed" before stimulation. The purpose of this study is to compare the effects of exercise and tDCS on memory performance in patients who have completed cardiac rehabilitation and are at risk of cognitive decline.
CONDITIONS
Official Title
Exercise as a Primer for Brain Stimulation in Vascular Cognitive Impairment No Dementia (VCIND)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 50 years of age or older; females must be post-menopausal
- Presence of cerebrovascular and/or cardiovascular risk factors or coronary artery disease
- Montreal Cognitive Assessment (MoCA) score less than 27
- Sufficient proficiency in English
- Ability to exercise at a moderate intensity level
- Presence of modest deficits (1 standard deviation below population norm) in executive function, verbal memory, working memory, or visuospatial memory
You will not qualify if you...
- History of stroke
- Change in psychotropic medications within the last 4 weeks
- Current benzodiazepine use
- Metal implants that prevent safe use of tDCS or neuroimaging
- Significant neurological or psychiatric conditions such as major depressive disorder, bipolar disorder, or schizophrenia
- MoCA score less than 18 and/or clinical diagnosis of dementia
- Any medical contraindications to exercise
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N 3M5
Actively Recruiting
Research Team
M
Mehreen Siddiqui
CONTACT
K
Kate Survilla
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here