Actively Recruiting
Exercise in Prostate Cancer
Led by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Updated on 2025-10-20
20
Participants Needed
1
Research Sites
223 weeks
Total Duration
On this page
Sponsors
S
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Lead Sponsor
P
Physical Medicine & Rehabilitation Educ Research Foundation, Inc
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn how exercise intervention affects circulating tumor cells (CTC) in men with advanced prostate cancer. The primary objective is to determine if an exercise intervention decreases CTCs in men with advanced prostate cancer. Participants will have baseline screening assessments, followed by 12 weeks of exercise intervention, and then follow-up assessments 12 weeks after the end of the exercise intervention.
CONDITIONS
Official Title
Exercise in Prostate Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men with metastatic prostate adenocarcinoma
- Currently taking androgen deprivation therapy alone or with oral androgen axis inhibitors for at least 3 months
- Elevated PSA greater than 1 ng/mL or rising PSA based on at least 2 readings at least 2 weeks apart
- Any number of prior cancer therapies allowed
- Positive circulating tumor cells (CTC+) by standard lab test
- Bone protective agents started at least 2 weeks before exercise intervention if needed
- Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1
- Cardiologist clearance if under cardiology care within past year
- Age 80 years or younger
You will not qualify if you...
- Small cell carcinoma of the prostate
- Unable to participate or monitor exercise due to conditions like impaired cognition
- Moderate to severe bone pain limiting daily activities or requiring narcotics
- Clinical progression needing change in systemic therapy or palliative radiation
- Bone metastases in spine or long bones requiring surgery or radiation due to fracture risk
- Significant cardiovascular disease or illness making 12 weeks of exercise unsafe without cardiologist approval
- Major surgery within the past 4 weeks
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Johns Hopkins University
Baltimore, Maryland, United States, 21287
Actively Recruiting
Research Team
R
Rana Sullivan, RN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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