Actively Recruiting
Exercise and Protein Efficiency in T2D
Led by University of Illinois at Urbana-Champaign · Updated on 2026-04-29
30
Participants Needed
1
Research Sites
124 weeks
Total Duration
On this page
Sponsors
U
University of Illinois at Urbana-Champaign
Lead Sponsor
A
American Diabetes Association
Collaborating Sponsor
AI-Summary
What this Trial Is About
In this randomized controlled trial, 30 older adults (aged\> 65 years; 15 with T2D, 15 controls) will participate in a 12-week progressive exercise training program. They will undergo pre- and post-testing that includes body composition measures; oral glucose tolerance testing; cardiovascular fitness and muscle performance testing; dietary protein efficiency assessed using the indicator amino acid oxidation (IAAO) method; and a gut microbiota trial. The dietary protein efficiency trial will include repeated ingestion of crystallized amino acids (drink) containing stable isotopes, urine samples, and breath samples. The gut microbiome trial will consist of a single ingestion of a Mediterranean-based modeled meal enriched with 13C-phenylalanine (in the drink) and repeated blood draws. Participants will also be asked to give a fecal sample after the gut microbiome trial.
CONDITIONS
Official Title
Exercise and Protein Efficiency in T2D
Who Can Participate
Eligibility Criteria
You may qualify if you...
- At least 65 years old
- Body mass index between 25 and 40 kg/m²
- Female participants must have a waist to hip ratio greater than 0.8
- Male participants must have a waist to hip ratio greater than 1.0
- Not engaged in structured exercise during the prior 6 months
- Weight stable for the prior 6 months
- For the T2D group: Diagnosed with type 2 diabetes and HbA1c over 6.5%
- For the control group: Normal blood sugar with HbA1c not exceeding 5.6% and fasting blood glucose at or below 99 mg/dL (5.5 mmol)
You will not qualify if you...
- Uncontrolled diabetes (HbA1c over 10% or prescribed insulin)
- Diagnosed diabetic neuropathy or failing diabetic neuropathy screening
- Current use of statin medications
- Presence of peripheral edema
- Use of dietary supplements affecting muscle mass (e.g., creatine, HMB), insulin-like substances, or anabolic/catabolic pro-hormones within 6 weeks prior
- Untreated hypothyroidism or epilepsy
- Use of medications affecting blood vessel activity
- Possibility of pregnancy
- Any neurological, cardiovascular, or musculoskeletal condition preventing exercise testing
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Freer Hall - University of Illinois
Urbana, Illinois, United States, 61801
Actively Recruiting
Research Team
N
Nicholas Burd (Professor), PhD
CONTACT
G
Gena Irwin (Research Assistant), M.S
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here