Actively Recruiting
Exercise to ReGain Stamina and Energy (The EXERGISE Study)
Led by University of Florida · Updated on 2026-02-05
24
Participants Needed
1
Research Sites
139 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
About 20%-70% of breast cancer survivors experience fatigue after cancer therapy. Because epidemiologic evidence shows that old age is a risk factor for fatigue in adults with cancer history, older breast cancer survivors suffer from even more fatigue than younger survivors. The purpose of this study is to test types of walking exercise interventions and their ability to reduce fatigue in older breast cancer survivors.
CONDITIONS
Official Title
Exercise to ReGain Stamina and Energy (The EXERGISE Study)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Consent to participate in the study
- Age 60 years or older
- Diagnosed with stage I-III invasive breast cancer
- Cancer diagnosis made in 2021 or 2022
- Completed adjuvant therapy at least 3 months ago but no more than 1 year ago
- Willing to participate in all study procedures
- Experience at least moderate fatigue (PROMIS raw score 8 or higher)
You will not qualify if you...
- Unable to provide informed consent
- Currently involved in a rehabilitation program
- Absolute contraindications to exercise training
- Significant cognitive impairment
- Progressive, degenerative neurological disease
- Had hip fracture, hip or knee replacement, or spinal surgery within the past 4 months
- Other serious health conditions that impair exercise participation
- Pregnant
- Regular use of nicotinamide riboside supplements
- Participating in other interventional studies
- No or very mild fatigue (PROMIS raw score 7 or lower)
- Diagnosed in past 3 years with coronary heart disease, angina, heart attack, heart failure, stroke, high blood pressure, chronic obstructive pulmonary disease, chronic bronchitis, arthritis, diabetes, or chronic kidney disease
- Received oral or intravenous antibiotics within 4 weeks prior to screening
- Used probiotics within 4 weeks prior to screening
- History of active treatment for HIV, hepatitis B, or hepatitis C
- Positive stool cultures for enteric pathogens including Clostridium difficile
- Excessive alcohol use or abuse
- Substance abuse within past 3 years
- Smoking history within past 3 years
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Institute on Aging; University of Florida
Gainesville, Florida, United States, 32611
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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