Actively Recruiting

Age: 18Years +
All Genders
NCT06179212

Exercise Testing Protocols for Females and Males With CAD

Led by Ottawa Heart Institute Research Corporation · Updated on 2026-03-12

54

Participants Needed

1

Research Sites

352 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The aim of this study is to determine if the test that allows males to achieve a higher VO2 (a measure of oxygen use during exercise) is different for females. The purpose of this study is to test 4 different exercise testing protocols to compare measured oxygen consumption in females and males with CAD (disease caused by the buildup of plaque in the artery walls which can lead to insufficient amounts of blood, nutrients and oxygen being supplied to the heart). The 4 exercise tests that will be completed on the treadmill are the modified Balke, modified Bruce, modified Naughton and University of Ottawa Heart Institute Slow Ramp protocols. Each test has a different stage duration (the amount of time that the test remains at a pre-determined speed and incline), and incremental increase in speed and incline. The main purpose of this study is to compare VO2 peak (the maximal amount of oxygen utilized during the exercise test) of females and males with CAD in 4 different exercise protocols. For example, the investigators will find out: 1. which exercise protocol is more likely to achieve a higher peak V̇O2 in females and which protocol is more likely to achieve a higher peak V̇O2 in males, 2. if enjoyment affects the duration of the test, and 3. how different exercise test protocols will provide different results of maximal oxygen used by the participant's body during the exercise test.

CONDITIONS

Official Title

Exercise Testing Protocols for Females and Males With CAD

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • 18 years and older
  • Previous diagnosis of coronary artery disease by a physician
  • Ability to perform cardiopulmonary exercise testing until volitional exhaustion
  • Ability to walk and exercise on a treadmill
  • At least 8 weeks post cardiovascular event or procedure (e.g., PCI, CABG)
  • Able to provide written informed consent
Not Eligible

You will not qualify if you...

  • Cannot speak, read, write, or understand English or French
  • Not currently enrolled in a cardiac rehabilitation program
  • Recent or planned change in physical activity levels within the last 4 weeks
  • Heart failure with an ejection fraction less than 45%
  • Presence of arrhythmia, peripheral artery disease, valvular disease, severe aortic stenosis, cardiomyopathy, SCAD, or COPD
  • Has an implantable cardioverter defibrillator (ICD)
  • Pregnant
  • Unable to complete submaximal exercise testing due to musculoskeletal limitations

AI-Screening

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Trial Site Locations

Total: 1 location

1

University of Ottawa Heart Institute

Ottawa, Ontario, Canada, K1Y 4W7

Actively Recruiting

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Research Team

J

Jennifer Reed, PhD

CONTACT

M

Matheus Mistura, MSc

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

1

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Exercise Testing Protocols for Females and Males With CAD | DecenTrialz