Actively Recruiting
Exercise Therapy to Improve Cardiovascular Health in Post-Menopausal Women After Treatment for Early Stage Breast Cancer
Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-03-25
152
Participants Needed
2
Research Sites
337 weeks
Total Duration
On this page
Sponsors
M
Memorial Sloan Kettering Cancer Center
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study will compare the effects on cardiorespiratory fitness (CRF) of aerobic exercise in different amounts (number of minutes/session) over different periods of time (number of weeks). Aerobic exercise is physical activity of light-to-moderate intensity that uses the large muscle groups (muscles in your legs, buttocks, back, and chest) and can be performed for at least 10 minutes. The researchers will study the effects of different exercise programs on how well the study participants' bodies use oxygen, how well their heart pumps blood, how well their lungs function, and how healthy their blood vessels are.
CONDITIONS
Official Title
Exercise Therapy to Improve Cardiovascular Health in Post-Menopausal Women After Treatment for Early Stage Breast Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 21-80 years
- Female
- Surgically removed early stage (I-III) primary breast cancer
- Post-menopausal defined by one of the following: age 45 or older with no menses for at least 2 years; chemically or surgically induced menopause confirmed by oncologist; estradiol level of 30 pg/mL or less
- At least one year but no more than five years since completing definitive cancer therapy (surgery plus radiation, chemotherapy, or trastuzumab)
- Exercise intolerance with VO2peak below predicted for active age and sex-matched individuals
- Able to complete a baseline cardiopulmonary exercise test without high-risk ECG findings or inappropriate exercise response
- Willing to comply with all study procedures
You will not qualify if you...
- Recent acute myocardial infarction within 3-5 days
- Unstable angina
- Uncontrolled arrhythmia causing symptoms or hemodynamic compromise
- Recurrent fainting (syncope)
- Active endocarditis
- Acute myocarditis or pericarditis
- Severe symptomatic aortic stenosis
- Uncontrolled heart failure
- Recent pulmonary embolus or infarction within 3 months
- Thrombosis of lower limbs
- Suspected dissecting aneurysm
- Uncontrolled asthma
- Pulmonary edema
- Respiratory failure
- Acute non-cardiopulmonary disorders affecting exercise (e.g., infection, renal failure, thyrotoxicosis)
- Any other actively treated cancer
- History of other cancer treated within past 3 years except non-melanoma skin cancer
- Stage IV metastatic disease
- Low oxygen saturation at rest (85% or less)
- Mental impairment preventing cooperation
- Any condition making participant unsuitable according to investigator
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Hartford Healthcare Cancer Institute @ Hartford Hospital (Data Collection Only)
Hartford, Connecticut, United States, 06102
Actively Recruiting
2
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
Research Team
J
Jessica Scott, PhD
CONTACT
L
Lee Jones, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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