Study of Exercise Therapy to Reduce Musculoskeletal Side Effects in Adults Aged 18 to 35 Starting Isotretinoin Treatment

What this Trial Is About

Researchers are studying the effects of exercise therapy on musculoskeletal pain and quality of life in people starting isotretinoin treatment, a vitamin A derivative used for severe acne. Isotretinoin can cause side effects including acute sacroiliitis, a painful inflammation of the sacroiliac joints. This study aims to explore how stretching and sacroiliac mobilization exercises may help reduce these side effects and improve daily life for patients. Participants will be randomly assigned to one of two groups one group will follow an 18-week exercise program focusing on stability, strength, and mobility with five sessions per week divided into three 6-week phases the other group will receive no exercise intervention and only take the medication. The exercise program includes foundational strength, low-impact cardio, core and hip stability, mobility, and full body integration exercises. The study will follow patients over six months with evaluations at baseline, 1 month, 3 months, and 6 months after starting isotretinoin. Researchers will measure musculoskeletal pain using a pressure algometer device and assess quality of life with the WHOQOL-Short Form questionnaire. Pain levels will also be tracked using a visual analogue scale. The study will compare these outcomes between the exercise and control groups to assess the impact of the exercise program on isotretinoin-related side effects.

Exercise Therapy for Isotretinoin Users