Actively Recruiting
Exercise Training on Brain Insulin Responsiveness
Led by University Hospital Tuebingen · Updated on 2023-11-08
40
Participants Needed
1
Research Sites
166 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The overarching goal of the current study is to investigate the effect of one acute bout of exercise on the brain insulin responsiveness in a cross-over study design. To this end, investigators will compare the effect of two single endurance exercise sessions with different intensities, namely moderate intensity continuous training (MICT) and high-intensity-interval-training (HIIT), which will be performed in a randomized order. This will be compared to a waiting control condition.
CONDITIONS
Official Title
Exercise Training on Brain Insulin Responsiveness
Who Can Participate
Eligibility Criteria
You may qualify if you...
- BMI between 63 19.5 to 39 kg/m2
- Less than 150 minutes per week of moderate-intensity physical activity
- Less than 75 minutes per week of vigorous-intensity exercise
- Written consent to participate in the study
- Written consent to be informed about incidental findings
You will not qualify if you...
- Diagnosis of type 2 diabetes or cardiovascular diseases such as heart failure, myocardial infarction, or stroke
- Limitations affecting ability to perform ergometer-based exercise (e.g., balance or orthopedic problems)
- Insufficient knowledge of the German language
- Unable to legally give consent
- Pregnancy or breastfeeding
- History of severe mental or physical disorders including neurological diseases (e.g., epilepsy, migraines)
- Use of psychotropic drugs
- Use of medications affecting glucose metabolism
- Regular use of pain relief drugs
- Use of anticoagulant medications
- Previous bariatric surgery
- Acute infection within the last 4 weeks
- Low hemoglobin levels (less than 12g/dl for women, less than 14 g/dl for men)
- Other diseases or conditions deemed risky by the investigator
- Current participation in another lifestyle intervention or pharmaceutical study
- Presence of non-removable metal implants such as pacemakers, insulin pumps, large tattoos, retainers, contraceptive coils, or surgical metal parts
- Claustrophobia
- Sensitivity to temperature changes
- Tinnitus or increased sensitivity to loud sounds
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University Clinic Tübingen, Department of Internal Medicine IV
Tübingen, Germany, 72076
Actively Recruiting
Research Team
S
Stephanie Kullmann, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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