Actively Recruiting
Exercise Training for Managing Major Depressive Disorder in Multiple Sclerosis
Led by University of Illinois at Chicago · Updated on 2025-06-11
146
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
Sponsors
U
University of Illinois at Chicago
Lead Sponsor
C
Congressionally Directed Medical Research Programs
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this research is to examine the effects of two different exercise training regimens for managing depression and improving other health indicators among persons with multiple sclerosis (MS). The project will enroll persons with MS and major depressive disorder (MDD) between 18 and 64 years of age. The investigators will enroll a total of 146 participants. This is a Phase-II trial that compares the efficacy of an exercise training program (POWER-MS) compared with a stretching program (FLEX-MS) for immediate and sustained reductions in the severity of depression among persons with MS who have MDD.
CONDITIONS
Official Title
Exercise Training for Managing Major Depressive Disorder in Multiple Sclerosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Physical confirmed diagnosis of Multiple Sclerosis (MS)
- Diagnosis of Major Depressive Disorder (MDD) as assessed by MINI
- Primary language is English
- Age between 18 and 64 years
- No MS relapse or steroid use in the past 30 days
- Access to internet and email
- Willingness to complete tests, questionnaires, wear accelerometer, undergo randomization, and participate in exercise testing
You will not qualify if you...
- Health contribution score of 14 or more on Godin Leisure Time Exercise Questionnaire indicating sufficient baseline physical activity
- Patient Determined Disease Steps score above 2 indicating more than mild walking disability
- Beck Depression Inventory-Fast Screen score less than 4 indicating very mild depression
- More than one yes response on Physical Activity Readiness Questionnaire indicating risk for exercise contraindications
- Telephone Interview for Cognitive Status score less than 18 indicating possible severe cognitive impairment
- Presence of severe mental illness such as obsessive-compulsive disorder, schizophrenia, bipolar disorder, or other psychotic disorders as per MINI interview
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Illinois at Chicago
Chicago, Illinois, United States, 60612
Actively Recruiting
Research Team
R
Robert W Motl, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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