Actively Recruiting
Exogenous Ketone Esters for Drug Resistant Epilepsy
Led by Sohag University · Updated on 2024-11-27
60
Participants Needed
1
Research Sites
129 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to investigate the efficacy of add-on exogenous ketone esters for treating children with drug-resistant epilepsy
CONDITIONS
Official Title
Exogenous Ketone Esters for Drug Resistant Epilepsy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Drug-resistant epilepsy
- Seizure frequency �3E= 7 per week
You will not qualify if you...
- Failure to obtain informed consent
- Recent intake of exogenous ketones, ketogenic diet, or any dietary restrictions/modifications
- Severe disease conditions, including hepatic, renal, respiratory, cardiac, gastrointestinal, endocrinal, and immune systems
- Hypo-/hyperglycemia
- Metabolic acidosis
- Ketosis (b2HB > 2 mmol/L)
- Gastrointestinal tract disorders, including gastritis/peptic ulcer, diarrhea/constipation, and irritable bowel disease
- Malnutrition or obesity
- Limitations to oral feeding such as severe gastroesophageal reflux
- Inborn errors of metabolism
- Chromosomal disorders
- Surgically-remediable epilepsy
- Allergies or any contraindication to ketone supplements
- Inapplicable recording of seizures
- Incompliance to anti-seizure medications and/or irregular follow-up
- Recent propofol therapy
- Intake of carbonic-anhydrase inhibitors
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Department of Pediatrics at Sohag University Hospital
Sohag, Egypt, 82524
Actively Recruiting
Research Team
E
Elsayed M Abdelkreem, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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